下丘脑弓状核KNDy神经元参与围绝经期潮热发生的机制  

Mechanism of KNDy neurons in arcuate nucleus of hypothalamus involved in the occurrence of perimenopausal hot flashes

作　　者：孙艳荣 戴立新 王文娟 王珂[1] 秦丽华[1] SUN Yan-rong;Dai Li-xin;WANG Wen-juan;WANG Ke;QING Li-hua(Department of Human Anatomy and Histoembryology,School of Basic Medical Sciences,Peking University Health Science Center,Beijing 100083,China;Pharmacy in Health Center of Gaoxing Town,Shandong Rizhao 276811,China)

机构地区：[1]北京大学医学部基础医学院人体解剖学与组织学胚胎学系,北京100083 [2]日照市岚山区高兴镇卫生院药房,山东日照276811

出　　处：《解剖学报》2021年第6期992-998,共7页Acta Anatomica Sinica

基　　金：国家自然科学基金(81873818)。

摘　　要：潮热是围绝经期女性最常见的特异性症状,严重危害女性的身心健康和生活质量。由于潮热的发病机制尚未明确,且现有的雌激素替代疗法存在诸多局限和禁忌,故探讨潮热的发病机制并寻找新的治疗靶点尤为迫切和重要。近年研究提示,围绝经期雌激素降低时下丘脑弓状核(ARC)中KNDy神经元异常是引起潮热的关键因素。部分学者认为,ARC中KNDy神经元通过调控促性腺激素释放激素及其下游促黄体生成素的脉冲释放参与潮热的发生;而另有学者认为,ARC中KNDy神经元通过调控下丘脑视前区的正中视前核在潮热发生过程中发挥关键作用。我们就上述两种关于ARC KNDy神经元与潮热发生之间的关系及其参与潮热的可能机制进行总结和概括,为探寻诊治围绝经期潮热的新靶点和新方法奠定理论基础。Hot flashes are the most common specific symptom of perimenopausal women,which seriously endangers their physical and mental health and quality of life. Because the pathogenesis of hot flashes is not yet clear,and existing estrogen replacement therapy has many limitations and contraindications,it is particularly urgent and important to explore the pathogenesis of hot flashes and find new therapeutic targets. Recent studies suggest that abnormalities of KNDy neurons in the arcuate nucleus of hypothalamus when estrogen decreases during perimenopause are the key factors that trigger hot flashes. Some scholars believe that KNDy neurons in the arcuate nucleus are involved in the occurrence of hot flashes by regulating the pulse release of gonadotropin-releasing hormone and its downstream luteinizing hormone,while some other scholars believe that KNDy neurons in the arcuate nucleus play a key role in the process of hot flashes by regulating the median preoptic nucleus of the hypothalamic preoptic area. Therefore,this review intends to summarize the above two types of current relationship between the KNDy neurons in the arcuate nucleus and the occurrence of hot flashes and the possible mechanisms by which KNDy neurons participate in hot flashes,and lay a theoretical foundation for the exploring of new targets and method for the treatment of perimenopausal hot flashes.

关 键 词：KNDy神经元 弓状核 促黄体生成素 促性腺激素释放激素 正中视前核 视前区 潮热 围绝经期 女性 

分 类 号：R711.75[医药卫生—妇产科学]