人脐带间充质干细胞修复子宫内膜损伤  

Human umbilical cord mesenchymal stem cells in endometrial injury repair

作　　者：刘星妤 胡小芳[1] 徐广立 王瑞[1] 李佩瑶 王梦园 彭丽 朱香颖 Liu Xingyu;Hu Xiaofang;Xu Guangli;Wang Rui;Li Peiyao;Wang Mengyuan;Peng Li;Zhu Xiangying(Department of Reproductive Medicine,First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan Province,China)

机构地区：[1]河南中医药大学第一附属医院生殖医学科,河南省郑州市450000

出　　处：《中国组织工程研究》2022年第24期3921-3927,共7页Chinese Journal of Tissue Engineering Research

基　　金：河南省医学科技攻关计划项目(LHGJ20170001),项目负责人:徐广立。

摘　　要：背景:人脐带间充质干细胞具有分化能力强、免疫调节作用强等特点,在细胞治疗方面受到广泛关注。目的:总结人脐带间充质干细胞治疗子宫内膜损伤相关疾病的研究进展。方法:以“人脐带间充质干细胞、子宫内膜、子宫内膜异位症、宫腔粘连、薄型子宫内膜”为中文检索词,以“human umbilical cord mesenchymal stem cells,endometrium,endometriosis,intrauterine adhesion,thin endometrium”为英文检索词,应用计算机检索PubMed、中国知网及万方数据库1991-2020年发表的相关文献,对64篇符合入组标准的文献进行综述分析。结果与结论:①人脐带间充质干细胞作为一种有相当发展潜力的干细胞,具有来源丰富、采集方便、细胞增殖和分化特性显著的特点。②人脐带间充质干细胞通过免疫调节、细胞分化及下调纤维化基因表达等途径,促进子宫内膜细胞损伤修复,减少瘢痕形成,改善子宫内膜功能,从而有利于胚胎着床和妊娠。③人脐带间充质干细胞移植治疗子宫内膜损伤发挥作用的重要机制可能与其旁分泌的各种细胞因子和营养因子有密切关系,这些因子参与了子宫内膜修复及免疫调节作用。④以人脐带间充质干细胞为基础的治疗方法在子宫内膜损伤疾病治疗中取得了一些有希望的成果,例如可抑制子宫内膜异位细胞的体外增殖和促进其凋亡,通过修复受损内膜从而恢复子宫内膜异位症大鼠的受孕能力,能够明显促进重度宫腔粘连综合征大鼠子宫内膜再生性修复,促进血管再生,恢复内膜功能,通过免疫调节特性使子宫内膜厚度增加,改善子宫内膜容受性,为治疗薄型子宫内膜提供新的思路。⑤人脐带间充质干细胞可以逃避机体免疫系统的识别,避开宿主监视,因而输注到体内不会引发强烈的排斥反应。⑥目前的此类研究多数仍局限于动物实验阶段,其在临床治疗中的应用并不广泛,未来�BACKGROUND:Human umbilical cord mesenchymal stem cells have the characteristics of strong differentiation and immunoregulation,which have been widely concerned in cell therapy.OBJECTIVE:To summarize the research progress of human umbilical cord mesenchymal stem cells in the treatment of endometrial related diseases.METHODS:Key words were“human umbilical cord mesenchymal stem cells,endometrium,endometriosis,intrauterine adhesions,thin endometrium”in Chinese and English.PubMed,CNKI,and Wanfang databases were retrieved for articles published from 1991 to 2020.Totally 64 articles meeting the inclusion criteria were reviewed and analyzed.RESULTS AND CONCLUSION:(1)Human umbilical cord mesenchymal stem cells,as a kind of stem cells with considerable development potential,have the advantages of rich sources,convenient collection,significant cell proliferation and differentiation.(2)Human umbilical cord mesenchymal stem cells promote the repair of endometrial cell injury,reduce scar formation and improve endometrial function through immune regulation,cell differentiation and down-regulation of fibrotic gene expression,which is conducive to embryo implantation and pregnancy.(3)The important mechanism of human umbilical cord mesenchymal stem cell transplantation for endometrium may be related to their paracrine cytokines and nutritional factors,and these factors participate in endometrial repair and immune regulation.(4)The treatment method based on human umbilical cord mesenchymal stem cells has achieved some promising results in the treatment of endometrial injury diseases,such as inhibiting the proliferation and promoting the apoptosis of endometrial cells in vitro,and restoring the fertility of endometriosis rats by repairing the damaged endometrium.It can remarkably promote the regenerative repair of endometrium in rats with severe intrauterine adhesion syndrome,promote vascular regeneration,restore endometrial function,increase the thickness of endometrium through immune regulation,improve endometrial receptivity,

关 键 词：干细胞 人脐带间充质干细胞 细胞分化 旁分泌 子宫内膜 子宫内膜异位症 宫腔粘连 薄型子宫内膜 

分 类 号：R459.9[医药卫生—治疗学] R363[医药卫生—临床医学]