便携式多参数动脉硬化检测系统研发  

Design of portable arteriosclerosis detection system with multi-parameter

作　　者：牛航舵 马胜才 李若薇 罗珺涵 叶继伦 张旭 NIU Hang-duo;MA Sheng-cai;LI Ruo-wei(School of Biomedical Engineering,Health Science Center,Shenzhen University,Shenzhen 518000,China)

机构地区：[1]深圳大学医学部生物医学工程学院,广东深圳518000 [2]深圳市生物医学重点实验室,广东深圳518000 [3]广东省生物医学信号检测与超声成像重点实验室,广东深圳518000

出　　处：《中国医学装备》2021年第12期1-5,共5页China Medical Equipment

基　　金：深圳市科创委重大产业关键技术研发项目(20190215140144982)“重2019N014麻醉用地氟烷蒸发器关键技术研发”。

摘　　要：目的:设计研发便携式多参数动脉硬化检测系统,并初步验证其临床应用的可靠性,全面地评估人体动脉硬化程度的可用性。方法:系统在传统动脉硬化仪器的基础上获取心电、心阻抗、血压和脉搏波四大生命体征信号,采用四电极法获取心电、心阻抗信号,通过袖带测量肱踝血压,通过指夹式光电传感器获取四通道同步连续脉搏波,基于脉搏波传导速度、踝臂指数、脉压并结合血液动力学参数,综合分析评估动脉硬化程度,并经临床试验完成对该系统的测试与验证。结果:系统硬件实现了生理信号的稳定获取,各项技术指标均优于相关标准,所测脉搏波传导速度、踝臂指数、脉压及血液动力学临床数据经统计学分析符合动脉硬化人群生理规律。结论:便携式多参数动脉硬化检测系统稳定可靠,能够为动脉硬化评估提供可靠测量参数,具有良好的应用前景。Objective:To design and construct a portable arteriosclerosis detection system with multi-parameter,and preliminarily verify its reliability in clinical application so as to evaluate the degree of arteriosclerosis more comprehensively.Methods:The system obtained the signals of four vital signs included electrocardiogram(ECG),impedance cardiogram,blood pressure and pulse wave on the basis of traditional atherosclerosis instrument.This system adopted four-electrode method to obtain the signals of ECG and impedance cardiogram,and measured blood pressure of humerus and ankle by the cuff of instrument,and obtained synchronous continuous pulse wave of four channels by finger clip photoelectric sensor.The degree of atherosclerosis was comprehensively analyzed and assessed on the basis of pulse wave velocity(PWV),the ankle-brachial index and the pulse pressure,and by combing with the hemodynamic parameters.And clinical trials were arranged to complete the test and verification of the system.Results:The system hardware realized the stable acquisition of physiological signals,and all the technical indicators were better than the relevant standards.The clinical data that included the measured PWV,the ankle-brachial index,the pulse pressure and hemodynamic parameters accorded with the physiological law of AS population as the statistical analysis.Conclusion:The portable arteriosclerosis detection system with multi-parameter is stable and reliable,which can provide reliable measurement parameters for the assessment of atherosclerosis,and it has a favorable application prospect.

关 键 词：动脉硬化 多参数 便携性 同步脉搏波 检测系统 

分 类 号：R318[医药卫生—生物医学工程]