双歧杆菌联合胃肠安丸与针刺对儿童功能性胃肠病的疗效及对MOT、5-HT的影响  

Efficacy of bifidobacterium combined with Weichang’an Pill and acupuncture on children with functional gastrointestinal disease and its influence on MOT and 5-HT

作　　者：芦秦梅 张金双 魏金霜 王立丽 胡晓 王丽 LU Qinmei;ZHANG Jinshuang;WEI Jinshuang;WANG Lili;HU Xiao;WANG Li(Department of Paediatrics,Tangshan Central Hospital,Tangshan,063000,China;Department of TCM,Tangshan Zhongjian Second Bureau Staff Hospital;Department of Paediatrics,Hiro-hito Hospital of Tangshan;Department of Paediatrics,Wuhan Central Hospital,Affiliated to Tongji Medical College of Huazhong University of Science and Technology)

机构地区：[1]唐山中心医院儿科,河北唐山063000 [2]唐山中建二局职工医院中医科 [3]唐山市弘慈医院儿科 [4]华中科技大学同济医学院附属武汉市中心医院儿科

出　　处：《中国中西医结合消化杂志》2021年第12期842-846,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：河北省中医药管理局2021年科研计划项目(No:2021431)。

摘　　要：目的:探究双歧杆菌联合胃肠安丸与针刺对儿童功能性胃肠病的疗效及对MOT、5-HT的影响。方法:选取2019年6月—2020年6月就诊的90例患者进行研究,按照住院的序列号前后,随机数表法对患者进行分组,研究组30例、对照组30例、双歧杆菌联合胃肠安丸组30例。研究组采用双歧杆菌联合胃肠安丸与针刺对患儿进行治疗。对照组采用双歧杆菌对患儿进行治疗。观察指标为临床主要症状、临床疗效、胃电图、血清相关胃肠激素。结果:对比3组在治疗前后的临床症状发生率,治疗前3组的临床症状差异无统计学意义(P>0.05),治疗后对照组恶心(5例)、呕吐(8例)、腹泻(8例)、腹痛(4例)例数均显著高于研究组(2例、4例、2例、1例),差异有统计学意义(P<0.05)。双歧杆菌联合胃肠安丸组腹痛(7例),腹泻(4例)要显著高于研究组(2例、1例)。研究组的临床治疗总有效率平均要优于对照组和双歧杆菌联合胃肠安丸组,差异有统计学意义(P<0.05),3组患者治疗后(餐前与餐后)胃动过缓以及胃电节律异常差异有统计学意义(P<0.05)。研究组治疗后胃电节律异常率和胃动过缓低于对照组和双歧杆菌联合胃肠安丸,差异有统计学意义(P<0.05)。对3组的血清进行比较,治疗前3组血清P物质(SP)、MOT、NO以及5-HT,差异无统计学意义(P>0.05),治疗后3组血清SP、MOT、NO以及5-HT水平都显著性升高,差异有统计学意义(P<0.05)。研究组指标平均高于对照组,双歧杆菌联合胃肠安丸组指标水平均高于对照组,差异有统计学意义(P<0.05)。结论:采用双歧杆菌联合胃肠安丸与针刺对儿童功能性胃肠病进行治疗,可以改善患者临床症状,提高临床疗效,值得在临床上进一步研究。Objective: To explore the effects of bifidobacteria combined with Weichang’an pill and acupuncture on children with functional gastrointestinal disease and the influences on MOT and 5-HT. Methods: Ninety patients in our hospital from June 2019 to June 2020 were selected for study. According to the serial number before and after hospitalization, the patients were randomly divided into study group(30 cases), control group(30 cases) and Bifidobacterium plus Weichang ’an Pill combination group(30 cases). The study group was treated with Bifidobacterium combined with Weichang ’an Pill and acupuncture. The control group was treated with Bifidobacterium. The main clinical symptoms, clinical efficacy, electrogastrogram and serum related gastrointestinal hormones were observed. Results: Compared with the incidence of clinical symptoms before and after treatment, there was no significant difference among the three groups before treatment(P>0.05). After treatment, the cases of nausea(5 cases), vomiting(8 cases), diarrhea(8 cases) and abdominal pain(4 cases) in the control group were significantly higher than those in the study group(2 cases, 4 cases, 2 cases, 1 case), with a significant difference(P<0.05). Abdominal pain(7 cases) and diarrhea(4 cases) in Bifidobacterium combined with Weichang ’an Pill group were significantly higher than those in the study group(2 cases, 1 case). The total effective rate of clinical treatment in the study group was better than that in the control group and Bifidobacterium combined with Weichang ’an Pill group, with a significant difference(P<0.05). After treatment, there were significant differences in bradycardia and abnormal gastric electrical rhythm among the three groups(P<0.05). After treatment, the abnormal rate of gastric electric rhythm and bradycardia in the study group were lower than those in the control group and Bifidobacterium combined with Weichang ’an Pill, with a significant difference(P<0.05). Comparing the serum of the three groups, there was no significant di

关 键 词：双歧杆菌 胃肠安丸 针刺 儿童 功能性胃肠病 

分 类 号：R725.7[医药卫生—儿科]