腺苷蛋氨酸联合门冬氨酸钾镁治疗小儿重度黄疸性肝炎的临床效果  

Clinical effect of ademetione combined with potassium magnesium aspartate in the treatment of severe icteric hepatitis in children

作　　者：林毅辉 潘万贵[1] LIN Yihui;PAN Wangui(Infectious Disease Department,Quanzhou Children's Hospital,Fujian Province,Quanzhou 362000,China)

机构地区：[1]福建省泉州市儿童医院感染科,362000

出　　处：《临床合理用药杂志》2021年第35期20-22,26,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察腺苷蛋氨酸联合门冬氨酸钾镁治疗小儿重度黄疸性肝炎的临床效果。方法选取2018年2月-2021年2月泉州市儿童医院收治的重度黄疸性肝炎确诊患儿60例,采用随机数字表法分为观察组和对照组,各30例。对照组予促肝细胞生长素联合门冬氨酸钾镁常规治疗,观察组予注射用丁二磺酸腺苷蛋氨酸联合门冬氨酸钾镁治疗。比较2组治疗效果、症状缓解时间,治疗前后肝功能指标[丙氨酸氨基转移酶(ALT)、白蛋白(ALB)、总胆红素(TB)、直接胆红素(DB)、总胆汁酸(TBA)、凝血酶原时间(PT)]、炎性指标[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)]变化及不良反应。结果治疗2周,观察组总有效率为93.33%,高于对照组的73.33%(χ^(2)=4.320,P=0.038);观察组各症状缓解时间均短于对照组(P<0.05或P<0.01);治疗2周后,2组ALT、TB、DB、TBA水平及PT和IL-6、TNF-α、hs-CRP水平均较治疗前下降,ALB水平较治疗前升高,且观察组下降或升高幅度大于对照组(P均<0.01);观察组患儿不良反应总发生率为6.67%,低于对照组的26.67%(χ^(2)=4.320,P=0.038)。结论腺苷蛋氨酸联合门冬氨酸钾镁治疗小儿重度黄疸性肝炎的临床效果显著,可有效缓解患儿症状,消除炎性反应和改善肝功能,且用药安全性高,值得临床推广应用。Objective To observe the clinical effect of ademetione combined with potassium magnesium aspartate in the treatment of severe icteric hepatitis in children. Methods Sixty children with severe icteric hepatitis treated in Quanzhou children’s Hospital from February 2018 to February 2021 were selected. All children were randomly divided into observation group and control group,with 30 cases in each group. The control group was treated with hemocyte growth promoting factor combined with potassium magnet aspartate,and the observation group was treated with ademetione combined with potassium magnet aspartate. The treatment effect,symptom relief time,the liver function indexes( ALT,ALB,TB,DB,TBA,PT)before and after treatment,inflammatory indexes( IL-6,TNF-α,hs-CRP) and the occurrence of adverse reactions were compared between the two groups. Results After 2 weeks of treatment,the total effective rate in the observation group was93. 33%,higher than 73. 33% in the control group( χ;= 4. 320,P = 0. 038). The remission time of symptoms in the observation group was shorter than that in the control group( P < 0. 05 or P < 0. 01). After 2 weeks of treatment,ALT,TB,DB,TBA,PT,IL-6 and TNF-α and hs-CRP in the two groups were lower than before treatment,ALB level was higher than before treatment,and the decrease or increase in the observation group was greater than that in the control group( P < 0. 01);The total incidence of adverse reactions in the observation group was 6. 67%,lower than 26. 67% in the control group( χ;= 4. 320,P = 0. 038).Conclusion Ademetione combined with potassium magnesium aspartate has a significant clinical effect in the treatment of severe icteric hepatitis in children. It can effectively alleviate the symptoms of children,eliminate inflammatory reaction and improve liver function. And the drug safety is high,which is worthy of clinical application.

关 键 词：小儿黄疸性肝炎 腺苷蛋氨酸 促肝细胞生长素 门冬氨酸钾镁 临床效果 

分 类 号：R725.7[医药卫生—儿科]