督灸配合药物治疗慢性阻塞性肺疾病稳定期疗效观察  

Efficacy Observation of Governor Vessel Moxibustion Combined with Medication for Chronic Obstructive Pulmonary Disease in Remission Stage

作　　者：翟春苗 李强[1] 王国栋 石占利[2] ZHAI Chun-miao;LI Qiang;WANG Guo-dong;SHI Zhan-li(Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou 310007,China;Zhejiang Integrated Traditional and Western Medicine Hospital,Hangzhou 310003,China)

机构地区：[1]杭州市中医院,杭州310007 [2]浙江省中西医结合医院,杭州310003

出　　处：《上海针灸杂志》2021年第12期1406-1411,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：浙江省中医药科技计划项目(2021ZB192);浙江省自然科学基金项目(Y20H290003)。

摘　　要：目的观察督灸配合药物治疗慢性阻塞性肺疾病(COPD)稳定期的临床疗效及其对患者呼吸功能及免疫平衡的影响。方法将60例COPD稳定期患者随机分为治疗组和对照组,每组30例。对照组采用常规药物及口服养肺益肾颗粒治疗,治疗组在对照组基础上采用督灸治疗。观察两组治疗前后临床症状体征总分、改良英国医学研究理事会呼吸困难指数(mMRC)、COPD评估测试(CAT)评分、肺功能各项指标[第1秒用力呼吸容积(FEVI)、FEV1与用力肺活量(FVC)比值]及血清γ-干扰素(IFN-γ)和白细胞介素-4(IL-4)水平的变化情况,并比较两组临床疗效。结果两组治疗后临床症状体征总分、mMRC、CAT评分与同组治疗前比较,差异均具有统计学意义(P<0.01)。治疗组治疗后各项肺功能指标及血清IFN-γ、IL-4水平均显著改善,与同组治疗前比较,差异均具有统计学意义(P<0.01);对照组治疗后FEV1/FVC和血清IFN-γ水平与同组治疗前比较,差异均具有统计学意义(P<0.01)。治疗组治疗后临床症状体征总分、mMRC、CAT评分、各项肺功能指标及血清IFN-γ、IL-4水平与对照组比较,差异具有统计学意义(P<0.01,P<0.05)。治疗组总有效率为90.0%,对照组为66.7%,两组比较差异具有统计学意义(P<0.01)。结论督灸配合药物是一种治疗COPD稳定期的有效方法,能改善患者呼吸功能及免疫平衡。Objective To observe the clinical efficacy of Governor Vessel moxibustion plus medication in treating remission-stage chronic obstructive pulmonary disease(COPD)and its effects on respiratory function and immune balance.Method Sixty patients with COPD in the remission stage were randomized into a treatment group and a control group,with 30 cases in each group.The control group was treated with the conventional medication plus oral administration of Yang Fei Yi Shen granules,while the treatment group was given additional Governor Vessel moxibustion.Before and after treatment,the total score of clinical symptoms and signs,modified British Medical Research Council(mMRC)dyspnea score,COPD assessment test(CAT)score,pulmonary function parameters[forced expiratory volume in one second(FEV1)and FEV1/forced vital capacity(FEV1/FVC)],and the levels of interferon(IFN)-γand interleukin(IL)-4 were observed.The clinical efficacy was also compared between the two groups.Result After treatment,the total score of clinical symptoms and signs,mMRC,and CAT scores significantly changed in both groups(P<0.01).The pulmonary function parameters and the levels of IFN-γand IL-4 significantly improved after the intervention in the treatment group,and the differences were statistically significant(P<0.01).After treatment,the EV1/FVC and the level of IFN-γsignificantly changed in the control group(P<0.01).After treatment,the total score of clinical symptoms and signs,mMRC and CAT scores,pulmonary function parameters,and the levels of IFN-γand IL-4 in the treatment group were markedly different from those in the control group(P<0.01,P<0.05).The total effective rate was 90.0%in the treatment group versus 66.7%in the control group,and the between-group difference was statistically significant(P<0.01).Conclusion Governor Vessel moxibustion plus medication is an effective approach to treat remission-stage COPD,and it can improve the respiratory function and immune balance of the patients.

关 键 词：灸法 药灸 隔姜灸 督灸 肺疾病 阻塞性 Γ-干扰素 白细胞介素-4 

分 类 号：R246.1[医药卫生—针灸推拿学]