甲状腺刺激性抗体水平和甲状腺体积等相关因素对Graves病患者停药后复发的预测价值  

Predicted Value of Recurrence of Thyroid Stimulating Antibody Level and Thyroid Volume and Other Related Factors in Patients with Graves Disease after Medicines Withdrawal

作　　者：胡蕾蕾 HU Leilei(Department of Laboratory,Specialist Hospital of Zhoukou Center for Disease Control and Prevention,Zhoukou City,He’nan Province 466000)

机构地区：[1]河南省周口市疾病预防控制中心专科病医院检验科,466000

出　　处：《医学理论与实践》2021年第24期4242-4244,共3页The Journal of Medical Theory and Practice

基　　金：河南省科技攻关项目(172102410011)。

摘　　要：目的:探讨甲状腺刺激性抗体水平和甲状腺体积等相关因素对Graves病患者停药后复发的临床价值。方法:回顾性分析我院2018年2月-2020年2月收治的123例Graves病患者,根据治疗结果分为复发组(63例)与未复发组(60例),同时选取本院61例健康体检者为对照组。观察两组患者血清促甲状腺激素受体抗体(TRAb)、血清甲状腺激素(T_(4))、三碘甲状腺原氨酸(T_(3))、游离三碘甲状腺氨酸(FT_(3))、促甲状腺素(TSH)、游离甲状腺素(FT_(4))及甲状腺体积等指标变化,并通过Spearman相关性分析,探讨各指标复发预测价值。对比甲状腺刺激性抗体水平、甲状腺体积、甲状腺功能检测检查结果。结果:未复发组TSH、FT_(4)、T_(3)、T_(4)、TRAb及甲状腺肿大程度均优于复发组(P<0.05)。经Spearman相关性检验,得出TSH与是否复发呈负相关(r=-0.530,P<0.05);FT_(4)、T_(3)、T_(4)和TRAb等指标与是否复发呈正相关性(r=0.784,P<0.001;r=0.825,P<0.001;r=0.773,P<0.001;r=0.797,P<0.001)。结论:Graves病患者停药后的TRAb水平、甲状腺体积与复发率呈正比,有一定的预测价值。Objective:To investigate the clinical value of related factors of thyroid stimulating antibody level and thyroid volume on the recurrence of patients with Graves disease after drug withdrawal.Methods:A retrospective analysis of 123 cases of Graves patients in our hospital in February 2018 to Februray 2020 was taken,patients were divided into the recurrence group(63 cases)and the non recurrence group(60 cases)according to treatment results,at the same time,61 cases of healthy people were selected as the control group.Serum thyroid-stimulating hormone receptor antibody(TRAb),serum thyroid hormone thyroxine(T_(4)),triiodothyronine(T_(3)),free triiodothyronine(FT_(3)),thyroid stimulating hormone(TSH),free thyroxine(FT_(4))and thyroid volume and other indicators change were recorded.By conducting Spearman correlation analysis,the predictive value of each indicator for recurrence was analyzed.Test results of thyroid stimulating antibody levels,thyroid volume,thyroid function test of the three groups were compared.Results:TSH,FT_(4),T_(3),T_(4),TRAb and the degree of goiter of the non recurrence group were better than those of the recurrence group(P<0.05).The Spearman correlation test showed that TSH was negatively correlated with recurrence(r=-0.530,P<0.05);FT_(4),T_(3),T_(4),and TRAb were positively correlated(r=0.784,P<0.001;r=0.825,P<0.001;r=0.773,P<0.001;r=0.797,P<0.001).Conclusion:The thyroid stimulating antibody level,thyroid volume in patients with Graves disease after medicines withdrawal are positively related to the recurrence rate,it has some predictive value.

关 键 词：甲状腺刺激性抗体 GRAVES病 甲状腺体积 复发预测 

分 类 号：R582.1[医药卫生—内分泌]