小而密低密度脂蛋白胆固醇对冠状动脉粥样硬化患者自噬诱导作用研究  

Study on the induction of autophagy in patients with coronary atherosclerosis by small and dense low-density lipoprotein cholesterol

作　　者：郭迎雪[1] 李俊峰[1] 高艺航[1] 邓沫[1] GUO Ying-xue;LI Jun-feng;GAO Yi-hang(Laboratory of the Second Hospital of Jilin University,Changchun 130041,China)

机构地区：[1]吉林大学第二医院检验科,吉林长春130041

出　　处：《中国实验诊断学》2021年第11期1614-1617,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探究小而密低密度脂蛋白胆固醇(sd LDL-C)对冠状动脉粥样硬化患者自噬诱导作用。方法选取自2018年1月1日-2020年5月30日间吉林大学第二医院收治拟行经皮冠状动脉介入术(PCI)的冠状动脉粥样硬化患者78例(粥样硬化组)和非粥样硬化冠脉病变患者45例(对照组)作为研究对象。观察两组患者血清sd LDL-C和冠脉标本中自噬相关蛋白表达水平。通过对粥样硬化组患者进行病变支数和狭窄程度亚组分析,观察其与sd LDL-C和自噬相关蛋白的相关性。结果粥样硬化组患者血清sd LDL-C、p62、NBR1和LC3-Ⅱ表达量显著高于对照组,差异具有统计学意义(P<0.05)。且sd LDL-C与p62(r=0.635)、NBR1(r=0.648)、LC3-Ⅱ(r=0.598)均呈正相关关系(P<0.05)。随着冠脉病变支数增多患者血清sd LDL-C、p62、NBR1和LC3-Ⅱ表达量显著升高,差异具有统计学意义(P<0.05)。随着狭窄程度的增加患者血清sd LDL-C、p62、NBR1和LC3-Ⅱ表达量显著升高,差异具有统计学意义(P<0.05)。结论sd LDL-C与冠脉粥样硬化病变支数和狭窄程度密切相关,其可能参与诱导了冠脉自噬。Objective To explore the effect of small and dense low-density lipoprotein cholesterol(sd LDL-C)on autophagy induction in patients with coronary atherosclerosis.Methods 78 patients with coronary atherosclerosis(atherosclerosis group)and non-atherosclerotic patients who were planned to undergo percutaneous coronary intervention(PCI)were admitted to our hospital from January 1,2018 to May 30,2020.Forty-five patients with sclerosing coronary artery disease(control group)were used as the research object.The expression levels of autophagy-related proteins in blood serum sd LDL-C and coronary artery specimens were observed in the two groups.Through subgroup analysis of the number of lesions and degree of stenosis of patients in atherosclerosis group,the correlation with sd LDL-C and autophagy-related proteins was observed.Results The expression of serum sd LDL-C,p62,NBR1 and LC3-Ⅱin the atherosclerosis group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).And sd LDL-C was positively correlated with p62(r=0.635),NBR1(r=0.648),LC3-Ⅱ(r=0.598)(P<0.05).With the increase in the number of coronary artery disease,the serum sd LDL-C,p62,NBR1 and LC3-Ⅱexpression increased significantly,and the difference was statistically significant(P<0.05).With the increase of the degree of stenosis,the expression of serum sd LDL-C,p62,NBR1 and LC3-Ⅱincreased significantly,and the difference was statistically significant(P<0.05).Conclusion sd LDL-C is closely related to the number of coronary atherosclerosis lesions and the degree of stenosis,and it may be involved in the induction of coronary autophagy.

关 键 词：小而密低密度脂蛋白胆固醇 冠状动脉粥样硬化 自噬诱导 

分 类 号：R541.4[医药卫生—心血管疾病]