深圳市330115例孕前优生健康检查育龄女性TORCH筛查结果分析  

Analysis of TORCH screening results of 330115 reproductive-age females who underwent pre-pregnancy health examination in Shenzhen

作　　者：杨娟 张月 张东梅 胡序怀 林薇薇 代巧云 陆草 赵君 关婷 Yang Juan;Zhang Yue;Zhang Dongmei;Hu Xuhuai;Lin Weiwei;Dai Qiaoyun;Lu Cao;Zhao Jun;Guan Ting(Shenzhen Health Development Research and Data Management Center,Shenzhen 518028,China;National Research Institute for Family Planning,Beijing 100081,China)

机构地区：[1]深圳市卫生健康发展研究和数据管理中心,518028 [2]国家卫生健康委科学技术研究所,北京100081

出　　处：《中华生殖与避孕杂志》2021年第11期1011-1018,共8页Chinese Journal of Reproduction and Contraception

基　　金：国家重点研发计划(2016YFC1000307);国家卫生健康委科学技术研究所所级课题(2018NRIFPJ03)。

摘　　要：目的:分析深圳市免费孕前优生健康检查育龄女性的TORCH筛查结果,以期指导科学备孕。方法:对2013年1月至2019年12月期间参加深圳市免费孕前优生健康检查的330115例育龄女性的TORCH筛查结果进行横断面研究,通过χ2检验分析TORCH筛查结果在不同年份、不同行政区域以及不同人口学特征育龄女性间的差异。结果:深圳市育龄女性风疹病毒(rubella virus,RV)-IgG、巨细胞病毒(cytomegalovirus,CMV)-IgG、CMV-IgM、刚地弓形虫(toxoplasma,TOX)-IgG、TOX-IgM筛查总体阳性率分别为85.54%(282377/330115)、96.36%(318088/330115)、0.31%(1009/330115)、3.12%(10292/330115)、0.64%(2114/330115),2017年至2019年较2013年至2016年育龄女性RV-IgG、CMV-IgG平均阳性率升高(P=0.003,P<0.001),TOX-IgG、TOX-IgM平均阳性率降低(P<0.001)。五种抗体阳性率在不同行政区域间的差异均有统计学意义(P均<0.001)。除CMV-IgM、TOX-IgM阳性率在不同年龄女性间的差异无统计学意义外,五种抗体阳性率在其他人口学特征育龄女性间的差异均有统计学意义(P均<0.05)。不同人口学特征女性在不同年份TORCH抗体阳性率的变化差异有统计学意义。结论:与2013年至2016年相比,2017年至2019年深圳市育龄女性RV-IgG、CMV-IgG阳性率有所升高,TOX-IgG、TOX-IgM阳性率有所下降。五种抗体阳性率在各区之间、不同人口学特征育龄女性间存在差异,提示在优生优育宣教时要因地制宜、因人而异地定改成订,强化优生意识,降低胎儿先天性宫内感染TORCH的风险。Objective To analyze the results of TORCH screening for reproductive-age females who underwent pre-pregnancy health examination in Shenzhen to guide scientific pregnancy preparation.Methods Cross-sectional study was performed on the TORCH screening results of 330115 reproductive-age females who participated in free pre-pregnancy health examination in Shenzhen from January,2013 to December,2019.Theχ2 test was used to analyze the differences of TORCH screening results among reproductive-age females in different years,administrative regions and demographic characteristics.Results The overall positive rates of screening for rubella virus(RV)-IgG,cytomegalovirus(CMV)-IgG,CMV-IgM,toxoplasma gondii(TOX)-IgG and TOX-IgM among reproductive-age females in Shenzhen were 85.54%(282377/330115),96.36%(318088/330115),0.31%(1009/330115),3.12%(10292/330115)and 0.64%(2114/330115),respectively.Compared with 2013 to 2016,the average positive rates of RV-IgG and CMV-IgG among reproductive-age females in Shenzhen increased(P=0.003,P<0.001),while the average positive rates of TOX-IgG and TOX-IgM decreased from 2017 to 2019(P<0.001).There were statistically significant differences in the positive rates of the five antibodies among different administrative regions(all P<0.001).Except for the differences in the positive rates of CMV-IgM and TOX-IgM among women of different ages,there were statistically significant differences in the positive rates of these five antibodies among reproductive-age females with other demographic characteristics(all P<0.05).There were statistical differences in the positive rates of TORCH antibodies among women with different demographic characteristics in different years.Conclusion Compared with 2013 to 2016,the positive rates of RV-IgG and CMV-IgG in reproductive-age females in Shenzhen from 2017 to 2019 were on the rise,while the positive rates of TOX-IgG and TOX-IgM were on the decline.The positive rates of these five antibodies were different among different administrative regions and among reproductive-

关 键 词：弓形虫属 风疹病毒 巨细胞病毒 孕前保健 育龄女性 

分 类 号：R169.1[医药卫生—公共卫生与预防医学]