Cellular and humoral immune interactions between Drosophila and its parasitoids  

作　　者：Lei Yang Li-Ming Qiu Qi Fang David W.Stanley Gong-Yin Ye 

机构地区：[1]State Key Laboratory of Rice Biology&Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects,Institute of Insect Sciences,Zhejiang University.Hangzhou,China [2]USD A Agricultural Research Service,Biological Control of Insects Research Laboratory,Columbia,Missouri,United States

出　　处：《Insect Science》2021年第5期1208-1227,共20页昆虫科学（英文版）

基　　金：the Key Program of Na-tional Natural Science Foundation of China(31830074);the Major International(Regional)Joint Research Project of NSFC(31620103915);the Program for Chinese Inno-vation Team in Key Areas of Science and Technology of the Ministry of Science and Technology of the People's Republic of China(2016RA4008);the Program for Chinese Outstanding Talents in Agricultural Scientific Research of the Ministry of Agriculture and Rural Af-fairs of the People's Republic of China.

摘　　要：The immune interactions occurring between parasitoids and their host insects,especially in Drosophila-wasp models,have long been the research focus of insect immunology and parasitology.Parasitoid infestation in Drosophila is counteracted by its multiple natural immune defense systems,which include cellular and humoral immunity,Occurring in the hemocoel,cellular immune responses involve the proliferation,differentiation,migration and spreading of host hemocytes and parasitoid encapsulation by them.Contrastingly,humoral immune responses rely more heavily on melanization and on the Toll,Imd and Jak/Stat immune pathways associated w ith antimicrobial peptides along with stress factors.On the wasps'side,successful development is achieved by introducing various virulence factors to counteract immune responses of Drosophila.Some or all of these factors manipulate the host's immunity for successful parasitism.Here we review current knowledge of the cellular and humoral immune interactions between Drosophila and its parasitoids,focusing on the defense mechanisms used by Drosophila and the strategies evolved by parasitic wasps to outwit it.

关 键 词：Drosophilas immunity PARASITOID VENOM virus-like particles 

分 类 号：Q96[生物学—昆虫学]