糖尿病因素对患者七氟烷肺摄取的影响  

Effect of diabetes mellitus on pulmonary uptake of sevoflurane

作　　者：安丽 刘艳秋 高鸿 段宏伟 钟毅 刘旸 赵怀彪 何幼芹 王贵龙 An Li;Liu Yanqiu;Gao Hong;Duan Hongwei;Zhong Yi;Liu Yang;Zhao Huaibiao;He Youqin;Wang Guilong(Department of Anesthesiology,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China;Department of Anesthesiology,Guiyang Fourth People′s Hospital,Guiyang 550002,China;The Third Affiliated Hospital of Guizhou Medical University,Duyun 558000,China;Department of Anesthesiology,Shanghai Pudong Hospital,Shanghai 201209,China;Department of Anesthesiology,Qianxinan People′s Hospital,Xingyi 562400,China;School of Anesthesiology,Guizhou Medical University,Guiyang 550004,China;Department of Anesthesiology,Zhijin County People′s Hospital,Bijie 552100,China)

机构地区：[1]贵州医科大学附属医院麻醉科,贵阳550004 [2]贵阳市第四人民医院麻醉科,550002 [3]贵州医科大学第三附属医院,都匀558000 [4]上海市浦东医院麻醉科,201209 [5]黔西南州人民医院麻醉科,兴义562400 [6]贵州医科大学麻醉学院,贵阳550004 [7]织金县人民医院麻醉科,毕节552100

出　　处：《中华麻醉学杂志》2021年第10期1227-1229,共3页Chinese Journal of Anesthesiology

基　　金：贵州省科技厅联合基金项目(黔科合LH字(2016)7252号)。

摘　　要：目的探讨糖尿病因素对患者七氟烷肺摄取的影响。方法选择择期行全麻手术的2型糖尿病患者20例为糖尿病组(D组),年龄40~64岁,BMI 18.5~22.9 kg/m2,ASA分级Ⅰ或Ⅱ级,并选择年龄、性别及手术均相匹配的非糖尿病择期手术患者20例为对照组(C组)。麻醉诱导气管插管术后,吸入七氟烷,吸入浓度2%(氧流量2 L/min)。于吸入七氟烷1、3、5、10、15、20、30 min时记录吸入浓度(Fi)和呼出浓度(Fa),并计算Fa/Fi比值。记录Fa/Fi比值达0.7所需时间。结果与C组比较,D组各时点Fa/Fi比值升高,Fa/Fi比值达0.7所需时间缩短(P<0.05)。结论糖尿病因素可减少患者七氟烷肺摄取。Objective To investigate the effect of diabetes mellitus on pulmonary uptake of sevoflurane.Methods Twenty patients with type 2 diabetes mellitus,aged 40-64 yr,with body mass index of 18.5-22.9 kg/m2,of American Society of Anesthesiologists physical statusⅠorⅡ,undergoing elective surgery with general anesthesia,served as diabetes group(group D).Twenty non-diabetic patients matched by age,gender and surgery were selected as control group(group C).After anesthesia induction and tracheal intubation,sevoflurane was inhaled at a concentration of 2%(oxygen flow 2 L/min).The inhaled concentration(Fi)and exhaled concentration(Fa)at 1,3,5,10,15,20 and 30 min of inhalation of sevoflurane were recorded,and the Fa/Fi ratio was calculated.The time required for the Fa/Fi ratio to reach 0.7 was recorded.Results Compared with group C,the Fa/Fi ratio was significantly increased at each time point,and the time required for the Fa/Fi ratio to reach 0.7 was shortened in group D(P<0.05).Conclusion Diabetes mellitus can reduce pulmonary uptake of sevoflurane in the patients.

关 键 词：糖尿病 麻醉药 吸入 呼吸道吸收 

分 类 号：R614[医药卫生—麻醉学] R587.1[医药卫生—外科学]