外周血miR-155表达对急性心肌梗死患者术后发生左心室重构的预测效果  

Prognostic effect of miR-155 expression in peripheral blood on left ventricular remodeling after acute myocardial infarction

作　　者：宋欢欢[1] 柴建文[1] 武鑫玲[1] 金玉[1] 张宁[1] Song Huanhuan;Chai Jianwen;Wu Xinling;Jin Yu;Zhang Ning

机构地区：[1]郑州人民医院心血管内科,450000

出　　处：《中国疗养医学》2022年第2期133-136,共4页Chinese Journal of Convalescent Medicine

摘　　要：目的探讨外周血miR-155表达对急性心肌梗死(AMI)患者术后发生左心室重构(LVR)的预测效果。方法选择2019年1月至2020年1月在郑州人民医院行经皮冠状动脉介入术(PCI)的AMI患者142例,术后随访1年,根据复查时超声心动图结果分为LVR组、非LVR组。术后7 d采用实时荧光定量PCR法测定两组患者外周血中miR-155的相对表达量。根据miR-155检测结果分组,高于平均值为高表达组,低于平均值为低表达组。采用多因素Logistics回归分析AMI患者术后1年发生LVR的影响因素,绘制ROC曲线分析外周血miR-155对AMI患者术后发生LVR的预测价值。结果142例患者中术后1年内发生LVR 33例,发生率为23.24%。LVR组外周血miR-155相对表达水平高于非LVR组(P<0.05)。miR-155高表达组LVR发生率高于miR-155低表达组(P<0.05)。外周血miR-155为AMI患者术后1年发生LVR的独立危险因素(OR=1.597,95%CI 0.866,2.943,P<0.05)。ROC曲线分析结果显示,外周血miR-155预测AMI患者术后1年发生LVR的曲线下面积为AUC为0.864,灵敏度为82.43%,特异度为86.02%。结论PCI术后7 d的外周血miR-155可用于AMI患者术后1年发生LVR的预测。Objective To investigate the prognostic effect of miR-155 expression in peripheral blood on left ventricular remodeling after acute myocardial infarction.Methods 142 patients with AMI who underwent percutaneous coronary intervention in Zhengzhou people's Hospital from January 2019 to January 2020 were selected.They were followed up for 1 year.They were divided into LVR group and non LVR group according to the echocardiographic results at the time of reexamination.The relative expression of miR-155 in peripheral blood of the two groups was measured by real-time fluorescence quantitative PCR 7 days after operation.According to the detection results of miR-155,the high expression group is higher than the average value,and the low expression group is lower than the average value.Multivariate logistic regression was used to analyze the influencing factors of LVR in patients with AMI one year after operation,and ROC curve was drawn to analyze the predictive value of peripheral blood miR-155 on LVR in patients with AMI.Results Among 142 patients,LVR occurred in 33 cases within 1 year after operation,with an incidence of 23.24%.The relative expression level of miR-155 in peripheral blood of the LVR group was higher than that of the non LVR group(P<0.05).The incidence of LVR in miR-155 high expression group was higher than that in miR-155 low expression group(P<0.05).MiR-155 in peripheral blood was an independent risk factor for LVR in patients with AMI one year after operation(OR=1.597,95%CI 0.866,2.943,P<0.05).ROC curve analysis showed that the area under the curve of peripheral blood miR-155 to predict LVR in patients with AMI one year after operation was AUC 0.864,the sensitivity was 82.43%,and the specificity was 86.02%.Conclusion Peripheral blood miR-1557 days after percutaneous coronary intervention can be used to predict LVR 1 year after AMI.

关 键 词：外周血miR-155 急性心肌梗死 左心室重构 经皮冠状动脉介入术 

分 类 号：R542.22[医药卫生—心血管疾病]