三周期极小化曲面单元结构骨小梁假体的生物力学性能  

Biomechanical properties of trabecular bone prosthesis with triply periodic minimal surfaces unit structure

作　　者：刘庆波 苏知杨 王恒峰 赵宇 吕嘉[3] Liu Qingbo;Su Zhiyang;Wang Hengfeng;Zhao Yu;Lyu Jia(College of Clinical Medicine,Dali University,Dali 671000,Yunnan Province,China;People’s Hospital of Xiangyun County,Dali 671000,Yunnan Province,China;Second Hospital of Shanxi Medical University,Taiyuan 030032,Shanxi Province,China)

机构地区：[1]大理大学临床学院,云南省大理市671000 [2]云南省大理州祥云县人民医院,云南省大理市671000 [3]山西医科大学第二医院,山西省太原市030000

出　　处：《中国组织工程研究》2022年第15期2297-2301,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81902273),课题名称:孔隙结构在3D打印多孔钛合金骨整合过程中的机制研究,项目负责人:吕嘉。

摘　　要：背景:3D打印骨小梁结构是新兴技术之一,其特有的结构和生物力学特性满足更多患者的临床需求,是未来精准医学的发展方向之一,但这一技术目前仍处于初步应用阶段,理论应用研究较少。目的:建立基于三周期极小化曲面单元结构的骨小梁假体生物力学有限元模型,分析不同曲面结构的生物力学性能差异。方法:以Matable软件根据函数公式生成曲面片结构,然后应用Magics 19.0设计三周期极小化曲面单元结构骨小梁假体,并在ABAQUS划分四面体网格,模拟人体站立状态下的受力环境。分析应力分布与位移,比较在宿主环境下的生物力学差异。结果与结论:①S曲面结构、D曲面结构、G曲面结构因孔隙率差异不大,生物力学差异不明显,相较于传统结构有明显改变,生物力学性能更优;②多孔结构的空隙率决定了假体的生物力学性能;③多孔结构假体的复合层出现层间结合容易出现应力突变现象;④多孔结构假体会明显减少植入体与宿主骨之间产生严重的应力遮挡效应。BACKGROUND:Three-dimensional printed trabecular bone structure is one of the emerging technologies,and the unique structural and biomechanical properties can meet the clinical needs of more patients,which has become one of the development directions of precision medicine in the future.However,application of this technology is still in its preliminary stage and little is reported on its theoretical application.OBJECTIVE:To establish a biomechanical finite element model of trabecular bone prosthesis based on triply periodic minimal surfaces unit structure,and to analyze the biomechanical differential properties of different curved surface structures.METHODS:The curved sheet structure was generated according to the function formula in Matable software,and then trabecular bone prosthesis with the triply periodic minimal surfaces unit structure was designed by Magics 19.0.The tetrahedral mesh was divided in ABAQUS to simulate the stress environment of the human body in standing position.The stress distribution and displacement were analyzed and the biomechanical differences in the host environment were compared.RESULTS AND CONCLUSION:S,D and G curved surface structures had no significant difference in porosity and biomechanical performance.Compared with the traditional structures,they had obvious changes and better biomechanical properties.The porosity of porous structure determined the biomechanical properties of the prosthesis.The composite layer of the porous prosthesis had interlayer bonding,which was prone to stress mutation.The porous structure could greatly reduce the severe stress shielding effect between the implant and the host bone.

关 键 词：骨小梁 3D打印 三周期极小化曲面 生物力学 有限元分析 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]