糖尿病动物皮肤损伤模型制备要素和受试物数据的文献分析  

Research Progress Related to Candidate Treatment Methods and Modeling Factors for Diabetic Animal Models with Skin Injury

作　　者：林江 骆飞 刘鹏 韩丝银 陈振兴 梁忠秀 兰太进 LIN Jiang;LUO Fei;LIU Peng;HAN Siyin;CHEN Zhenxing;LIANG Zhongxiu;LAN Taijin(School of Basic Medical Science,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学基础医学院,南宁530200

出　　处：《实验动物与比较医学》2021年第6期515-520,共6页Laboratory Animal and Comparative Medicine

基　　金：国家自然科学基金(81903919);广西科技基地和人才专项(桂科AD17195080);国家级海洋经济创新发展示范城市产业链协调创新项目(Bhsfs002);"北部湾海洋医药研究与开发"广西特聘专家岗位(2017[40]号);广西中药药效研究重点实验室(省级)开放课题(051-06-K6)。

摘　　要：目前,多种药物或方法已用于糖尿病创面不愈的治疗,包括中药、西药、生物制剂、物理疗法等,均取得了较好的临床治疗效果,但长期疗效还有待进一步提高。另外,糖尿病创面不愈是多种细胞及细胞因子相互作用的结果,单一疗法往往效果不显著。因此,在建立稳定可靠的动物模型基础上,通过药理学研究明确各药物或治疗手段的作用机制,可为后续临床联合应用提供治疗依据,以此提高临床治疗效果。本文收集国内外24年来有关糖尿病动物皮肤损伤模型的文献,统计分析模型制备要素及受试物(药物或治疗手段)数据,以期为提高造模效率和科学评价受试物提供依据。Currently,multiple drugs and other therapies are used for diabetic wounds,including Chinese herbs,Western medicine,biological agents,and physical therapy,these agents have been shown to be associated with favorable clinical outcomes,however,their long-term efficacy needs to be further improved.A diabetic wound is the result of an interaction among multiple cells and cytokines,and therefore a single treatment method is often ineffective.On the basis of establishing stable and reliable animal models,the mechanism underlying each treatment method can be clarified through pharmacological research,providing a basis for combined clinical application and improved clinical outcomes.In this paper,the scientific literature related to diabetic animal models with skin injury from the last 24 years was collected,and the factors involved in animal model preparation and treatment data were statistically analyzed to provide references for improving the modeling efficiency and scientifically evaluating the effectiveness of treatment methods.

关 键 词：糖尿病 动物模型 皮肤损伤 造模要素 受试物 

分 类 号：R-332[医药卫生] R587.2