靶向胰腺癌基质治疗策略研究进展  

Advances in research on therapeutic strategies of targeting pancreatic can⁃cer stroma

作　　者：周新源 刘楠 张盼 霍美蓉 ZHOU Xinyuan;LIU Nan;ZHANG Pan;HUO Meirong(Department of Pharmaceutics,School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学药学院药剂系,南京210009

出　　处：《中国药科大学学报》2021年第6期653-662,共10页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.82073175,No.81872424)。

摘　　要：胰腺癌基质在肿瘤进展、侵袭、转移和治疗抵抗中扮演着重要角色,单纯的靶向肿瘤细胞治疗策略已无法满足延长患者生存期的临床治疗需求。越来越多的研究着眼于靶向胰腺癌基质治疗与化疗、放疗和免疫疗法联合用药方案的开发。胰腺癌复杂的基质成分、互相串扰的信号通路和畸形增生的新生血管给靶向药物的研究开发带来了巨大挑战的同时也提供了相应的机遇。本文主要从细胞外基质(extracellular matrix,ECM)、肿瘤相关成纤维细胞(cancer associated fibroblasts,CAFs)和血管3个方面,综述了近期靶向胰腺癌基质治疗策略研究进展并加以分析讨论,以期为胰腺癌的靶向治疗提供新思路。Pancreatic cancer stroma plays a critical role in tumor progression,invasion,metastasis and resis⁃tance.Targeting tumor cell alone could not meet the demand for prolonging patients'survival.Growing studies have laid emphasis on developing combined regimens between targeting pancreatic cancer stroma and chemo⁃therapy,radiotherapy and immunotherapy.We are faced with some new opportunities in spite of the great chal⁃lenges brought to the research and development of targeting drugs owing to the complicated stroma components,crosstalking signal pathways and abnormal angiogenesis of pancreatic cancer.In this article,recent advances in therapeutic strategies of targeting pancreatic cancer stroma are reviewed and analyzed from the aspects of extra⁃cellular matrix(ECM),cancer associated fibroblasts(CAFs)and vessels,in the hope of providing some novel ideas for targeting therapy against pancreatic cancer.

关 键 词：胰腺癌 靶向基质 细胞外基质 肿瘤相关成纤维细胞 抗血管新生 进展 

分 类 号：R979.1[医药卫生—药品] R944[医药卫生—药学]