减数分裂联会复合体异常与不孕不育相关性研究进展  

Progress on the correlation between the abnormal synaptonemal complex and infertility

作　　者：聂辉 张译文 李佳宁 王楠楠 徐澜 Hui Nie;Yiwen Zhang;Jianing Li;Nannan Wang;Lan Xu(College of Life Sciences,Shandong Normal University,Jinan 250014,China)

机构地区：[1]山东师范大学生命科学学院,济南250014

出　　处：《遗传》2021年第12期1142-1148,共7页Hereditas（Beijing)

基　　金：山东省自然科学基金项目(编号:ZR2019PC050);山东师范大学大学生创新创业训练计划项目(编号:S202010445162)资助。

摘　　要：减数分裂是由二倍体的生殖细胞产生单倍体的配子的过程,是有性生殖的核心。联会复合体是同源染色体之间形成的超分子结构,具有稳定同源染色体配对、促进遗传交叉形成等功能。越来越多的研究表明联会复合体异常是造成人类不孕不育的重要原因之一。本文主要综述了联会复合体中央区域异常(如SYCE1/2/3、TEX12、SIX6OS1、SYCP1突变)及侧向元件缺陷(如SYCP2、SYCP3突变)与不孕不育的相关性研究,以期为深入理解减数分裂错误导致生殖健康问题的病理机制提供理论参考。Meiosis,the process of producing haploid gametes from diploid germ cells,acts as the core of sexual reproduction.The synaptonemal complex(SC)is a complex structure formed between homologous chromosomes,which can stabilize the pairing of homologous chromosomes and promote the formation of genetic crossover.More and more evidence suggested that the abnormal synaptonemal complex is closely associated with human infertility.In this review,we summarize the correlation between aberrant central region(CR)components(such as SYCE1/2/3,TEX12,SIX6OS1,SYCP1 mutations)or lateral elements(LE)(such as SYCP2,SYCP3 mutations)and infertility,in order to provide references for further understanding of the pathological mechanisms underlying reproductive health problems caused by meiotic errors.

关 键 词：减数分裂 联会复合体 不孕不育 

分 类 号：R711.6[医药卫生—妇产科学]