中国南部地区表观健康人群Lp-PLA2水平分布及其与LDL-C、hs-CRP的相关性分析  

A preliminary study on Lp-PLA2 and its relationship with LDL-C and hs-CRP in southern China

作　　者：赵晶晶[1] 张鹏[1] 周湧 曹颖平[3] 黄之虎[4] 符生苗[5] 王玉明[6] 洪国粦[7] 沈军[8] 郑磊[1] ZHAO Jingjing;ZHANG Peng;ZHOU Yong;CAO Yingping;HUANG Zhihu;FU Shengmiao;WANG Yuming;HONG Guolin;SHEN Jun;ZHENG Lei(Department of Clinical Laboratory,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong,China;Department of Clinical Laboratory,Dongguan Fifth People's Hospital,Dongguan 523000,Guangdong,China;Department of Clinical Laboratory,Union Hospital Affiliated to Fujian Medical University,Fuzhou 350001,Fujian,China;Department of Clinical Laboratory,Guangxi Zhuang Autonomous Region People's Hospital,Nanning 530001,Guangxi,China;Department of Clinical Laboratory,Hainan Provincial People's Hospital,Haikou 570311,Hainan,China;Department of Clinical Laboratory,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,Yunnan,China;Department of Clinical Laboratory,the First Affiliated Hospital of Xiamen University,Xiamen 350213,Fujian,China;Department of Clinical Laboratory,Shanghai General Hospital,Shanghai 200080,China)

机构地区：[1]南方医科大学南方医院检验医学科,广东广州510515 [2]东莞市第五人民医院检验科,广东东莞523000 [3]福建医科大学附属协和医院检验科,福建福州350001 [4]广西壮族自治区民族医院检验科,广西南宁530001 [5]海南省人民医院检验科,海南海口570311 [6]昆明医科大学附属第二医院检验科,云南昆明650101 [7]厦门大学附属第一医院检验科,福建厦门350213 [8]上海市第一人民医院检验科,上海200080

出　　处：《检验医学》2021年第12期1222-1228,共7页Laboratory Medicine

摘　　要：目的探讨中国南部地区表观健康人群脂蛋白相关磷脂酶A2(Lp-PLA2)水平分布及其与低密度脂蛋白胆固醇(LDL-C)、高敏C反应蛋白(hs-CRP)的相关性。方法选取中国南部地区8家三级甲等医院健康体检者2318名,检测血清Lp-PLA2及血脂[总胆固醇(TC)、三酰甘油(TG)、LDL-C、高密度脂蛋白胆固醇(HDL-C)]、hs-CRP水平,将所有对象按性别和年龄(<50岁、50~59岁、60~69岁、70~79岁、≥80岁)分别分组。采用Pearson相关分析或Spearman相关分析评估各项目之间的相关性。结果中国南部地区2318名表观健康者血清Lp-PLA2总体水平为(145.84±43.96)ng/mL,参考区间上限为217.93 ng/mL。女性血清Lp-PLA2水平低于男性(P<0.05)。<50岁组血清Lp-PLA2水平低于50~59岁组、60~69岁组及70~79岁组(P<0.05),与≥80岁组差异无统计学意义(P>0.05);50~59岁组、60~69岁组及70~79岁组之间血清Lp-PLA2水平差异均无统计学意义(P>0.05)。8家医院中,福建医科大学附属协和医院的血清Lp-PLA2检测结果最低,海南省人民医院的检测结果最高,与其他医院比较,差异均有统计学意义(P<0.05)。相关分析结果显示,Lp-PLA2与LDL-C呈正相关(r=0.163,P<0.05),与TC、TG、HDL-C和hs-CRP均无相关性(r值分别为-0.028、0.000、0.001、0.088,P>0.05)。结论初步建立了中国南部地区表观健康人群血清Lp-PLA2的参考区间。Objective To investigate the distribution of lipoprotein-associated phospholipase A2(Lp-PLA2)levels in southern China,and to evaluate the relationship between Lp-PLA2 and low-density lipoprotein cholesterol(LDL-C),high-sensitivity C-reactive protein(hs-CRP).Methods A total of 2318 serum samples were collected from 8 Grade 3 Class A hospitals in southern China.Lp-PLA2,blood lipids[total cholesterol(TC),triglyceride(TG)and high-density lipoprotein cholesterol(HDL-C)]and hs-CRP levels were determined.All the subjects were classified according to sex and ages(<50 years old,50-59 years old,60-69 years old,70-79 years old and≥80 years old).Pearson or Spearman correlation analysis was performed to evaluate the correlations between the items.Results The Lp-PLA2 level of 2318 healthy subjects in southern China was(145.84±43.96)ng/mL,and the upper limit of reference interval was 217.93 ng/mL.The level of serum Lp-PLA2 in females was lower than that in maless(P<0.05).The level of serum Lp-PLA2 in<50 years old group was lower than those in 50-59,60-69 and 70-79 years old groups(P<0.05),and there was no statistical significance compared with that in≥80 years old group(P>0.05).There was no statistical significance in serum Lp-PLA2 levels among 50-59,60-69 and 70-79 years old groups(P>0.05).Among the 8 hospitals,the level of Lp-PLA2 in the Union Hospital Affiliated to Fujian Medical University was the lowest,while the level of Lp-PLA2 in Hainan Provincial People’s Hospital was the highest,and there was statistical significance compared with the other hospitals(P<0.05).Lp-PLA2 was positively correlated with LDL-C(r=0.163,P<0.05),and there was no correlation with TC,TG,HDL-C and hs-CRP(r values were-0.028,0.000,0.001 and 0.088,P>0.05,respectively).Conclusions The reference interval of LpPLA2 in healthy subjects in southern China has been established preliminarily.

关 键 词：脂蛋白相关磷脂酶A2 低密度脂蛋白胆固醇 高敏C反应蛋白 

分 类 号：Q556[生物学—生物化学]