不同孕期单胎孕妇血清维生素E水平分布范围的调查  

Analysis of serum vitamin E level and distribution range in single pregnant women during different gestational weeks

作　　者：王鹏[1] 泰淑红[1] 孟祥颖[1] 牛超[1] 李松磊[1] 袁恩武[1] WANG Peng;TAI Shuhong;MENG Xiangying;NIU Chao;LI Songlei;YUAN Enwu(Department of Clinical Laboratory,Henan Maternity and Child Care Center,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,China)

机构地区：[1]河南省妇幼保健院郑州大学第三附属医院检验科,河南郑州450052

出　　处：《检验医学》2021年第12期1234-1237,共4页Laboratory Medicine

基　　金：河南省重点研发与推广专项科技攻关项目(182102310393)。

摘　　要：目的探讨单胎孕妇不同孕期血清维生素E(Vit E)水平的分布范围。方法选取孕前体检女性478名(未孕组)、围产保健单胎孕妇3 558例,年龄均为20~35岁。孕妇根据孕周分为孕6~8周、孕9~12周、孕13~16周、孕17~20周、孕21~24周、孕25~28周、孕29~32周、孕33~36周及孕37~40周9个组。采用高效液相色谱法检测所有对象血清Vit E水平。采用Spearman相关分析评估血清Vit E水平与孕期的相关性。采用百分位数法[P50(P2.5~P97.5)]确定不同孕期Vit E的分布范围。结果未孕组不同年龄段女性血清Vit E水平差异均无统计学意义(P>0.05)。除未孕组、孕6~8周组和孕9~12周组之间以及孕29~32周组、孕33~36周组和孕37~40周组之间血清Vit E水平差异均无统计学意义(P>0.05)外,其他孕期各组血清Vit E水平均随孕期的延长逐渐升高(P<0.05、P<0.01)。Spearman相关分析结果显示,血清Vit E水平与孕期呈正相关(r=0.66,P<0.01)。合并血清Vit E水平差异无统计学意义的孕期组后,采用百分位数法确定不同孕期血清Vit E水平的分布范围:孕6~12周为10.00(6.20~17.11)mg/L、孕13~16周为11.60(7.70~18.29)mg/L、孕17~20周为12.60(8.70~18.20)mg/L、孕21~24周为14.00(9.40~21.40)mg/L、孕25~28周为15.20(9.70~22.50)mg/L、孕29~40周为16.80(10.11~25.50)mg/L。结论单胎孕妇血清Vit E水平在孕13~28周时随孕周的增长而逐步升高,孕21周后血清Vit E水平分布范围的上限高于成人参考区间上限。Objective To investigate the distribution range of serum vitamin E(Vit E) levels in single pregnant women during different gestational weeks. Methods A total of 478 non-pregnant and 3 558 single pregnant women aged 20-35 years and took progestational or gestational healthy examination were enrolled. According to gestational weeks,these pregnant women were classified into 9 groups,6-8,9-12,13-16,17-20,21-24,25-28,29-32,33-36 and 37-40 gestational week groups. Based on the method of high-performance liquid chromatography,the levels of Vit E in serum were evaluated. Spearman correlation analysis was used to evaluate the correlation between serum Vit E level and pregnancy. The percentile method [P50(P2.5-P97.5)] was used to determine the distribution range of Vit E during different gestational weeks. Results Vit E levels in serum of nonpregnant women had no statistical significance among the age groups(P>0.05). The difference of Vit E levels had no statistical significance among the non-pregnant,6-8,9-12 gestational week groups,and among the 29-32,33-36,37-40 gestational week groups(P>0.05). The levels of Vit E gradually increased with the pregnancy in 13-16,17-20,21-24,25-28 gestational week groups(P<0.05,P<0.01). By Spearman correlation analysis,the Vit E levels had a positive correlation with the gestational weeks(r=0.66,P<0.01). Merged the gestational weeks whose Vit E levels had no statistical significance,the distribution ranges of serum Vit E level in different gestational weeks were established by percentile method:6-12 gestational weeks 10.00(6.20-17.11) mg/L,13-16 gestational weeks 11.60(7.70-18.29) mg/L,17-20 gestational weeks 12.60(8.70-18.20) mg/L,21-24 gestational weeks 14.00(9.40-21.40) mg/L,25-28 gestational weeks 15.20(9.70-22.50) mg/L and 29-40 gestational weeks 16.80(10.11-25.50) mg/L. Conclusions From 13 to 28 gestational weeks,the level of Vit E increases. The upper limit of Vit E distribution ranges in the groups of 21-40 gestational weeks is higher than that of healthy adults.

关 键 词：维生素E 妊娠期 分布范围 

分 类 号：Q566[生物学—生物化学]