C242T基因多态性与冠心病的相关性  

The Relationship Between C242T Gene Polymorphism and Coronary Heart Disease

作　　者：毛山[1] 周明[1] 王俊峰[1] 李军[1] 曹政[1] MAO Shan;ZHOU Ming;WANG Junfeng(Taihe Hospital,Hubei Shiyan 442000,China)

机构地区：[1]湖北省十堰市太和医院心内科,湖北十堰442000

出　　处：《河北医学》2021年第12期1969-1974,共6页Hebei Medicine

基　　金：湖北省自然科学基金计划项目,(编号:2018CFB537)。

摘　　要：目的:探讨分析C242T基因多态性与冠心病的相关性。方法:选取2019年10月―2020年10月我院收治的118例冠心病患者作为观察组,并选取同期体检无冠心病的96例体检者作为对照组,所有入组研究对象均采用美国OMEGA公司基因提取试剂盒检测C242T基因多态性(基因亚型和等位基因频率)。比较两组研究对象一般资料,及C242T基因中不同亚型和等位基因频率分布情况,并采用Logistic回归分析C242T基因与冠心病的相关性。结果:观察组高血压史、糖尿病史发生率高于对照组,且TG、TC、HDL-C、Hs-CRP、BNP、HCY、LP(a)、WBC等指标水平高于对照组(P<0.05);观察组C242T基因中TT型、CT型基因频率和T等位基因频率分布均显著高于对照组(P<0.05);TT+CT型基因携带患者HDL-C水平显著低于CC型基因携带患者(P<0.05),而不同基因型患者间其他血脂指标水平无明显差异(P>0.05);对有统计学差异的相关因素进行Logistic回归分析,结果显示,糖尿病(OR=1.422,95%CI:1.164~1.737)、HDL-C(OR=1.534,95%CI:1.011~2.329)、HCY(OR=1.241,95%CI:1.159~1.329)、携带T型基因(OR=1.265,95%CI:1.151~1.390)是冠心病的独立危险因素(P<0.05)。结论:C242T基因中TT、CC基因型与冠心病的发生相关,在冠心病患者体内TT型、CC型分布频率较高,且T型基因携带者冠心病发病风险更高,可为临床诊断及防治提供指导依据。Objective:To explore and analyze the correlation between C242T gene polymorphism and coronary heart disease.Methods:A total of 79 patients with coronary heart disease admitted to our hospital from October 2019 to October 2020 were selected as the observation group,and another 96 cases with no coronary heart disease were made the control group.All the enrolled subjects underwent detection of C242T gene polymorphism(gene subtype and allele frequency)with the American OMEGA gene extraction reagent Box.The general data of the two groups of research subjects were compared,and the frequency distribution of different subtypes and alleles in the C242T gene were compared,and the correlation between the C242T gene and coronary heart disease was analyzed by Logistic regression.Results:The incidence of history of hypertension and diabetes in the observation group was higher than that of the control group,and the levels of TG,TC,HDL-C,Hs-CRP,BNP,HCY,LP(a),WBC and other indicators were higher than those of the control group(P<0.05);the frequency distribution of TT type,CT type gene and T allele frequency in the C242T gene of the observation group were significantly higher than those of the control group(P<0.05);the level of HDL-C in patients with TT+CT gene carriers was significantly lower than that in patients with CC gene carriers(P<0.05),while there was no significant difference in the levels of other blood lipid indexes among patients with different genotypes(P>0.05);logistic regression analysis was performed on the relevant factors with statistical differences,and the results showed,diabetes(OR=1.422,95%CI:1.164~1.737),HDL-C(OR=1.534,95%CI:1.011~2.329),HCY(OR=1.241,95%CI:1.159~1.329),carrying T-type gene(OR=1.265,95%CI:1.151~1.390)are independent risk factors for coronary heart disease(P<0.05).Conclusion:The TT and CC genotypes in the C242T gene are related to the occurrence of coronary heart disease.TT and CC types are distributed more frequently in patients with coronary heart disease,and T-type gene carriers are at hig

关 键 词：C242T基因 基因型 基因频率 冠心病 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]