布地奈德及特布他林与噻托溴铵对老年COPD急性加重期患者的效果观察  

Effect of Budonide and Tebutalin and thitropium bromide on elderly patients with acute aggravation period of COPD

作　　者：王小敏 WANG Xiao-min(Department of Respiratory and Critical Care Medicine of Xiuwu County People's Hospital Xiuwu County,Xiuwu 454350 China)

机构地区：[1]河南省修武县人民医院呼吸与危重症医学科,河南修武454350

出　　处：《内蒙古医学杂志》2021年第12期1444-1446,共3页Inner Mongolia Medical Journal

基　　金：河南省医学科技攻关计划项目(编号:201901335)。

摘　　要：目的探究布地奈德及特布他林与噻托溴铵治疗急性加重期慢性阻塞性肺疾(AECOPD)患者的临床效果。方法纳入2019年10月至2020年11月我院收治的124例老年慢性阻塞性肺疾病急性加重期患者,按随机数字表法分为两组,各62例。对照组给予布地奈德混悬液+特布他林治疗,观察组给予噻托溴铵粉雾剂治疗。比较两组肺功能、血气指标、炎性因子水平及安全性。结果观察组第1秒用力呼气容积(FEV1)、FEV1/用力肺活量(FVC)、动脉血氧分压(PaO_(2))分别为(1.44±0.20)L、(66.24±7.65)%、(83.94±7.62)mmHg,高于对照组的(1.05±0.17)L、(61.83±7.82)%、(64.52±5.13)mmHg,二氧化碳分压(PaCO_(2))、C反应蛋白(CRP)、白介素-6(IL-6)为(42.55±5.11)mmHg、(1.03±0.38)mg/L、(18.17±8.63)pg/ml,低于对照组的(54.98±5.13)mmHg、(1.44±0.47)mg/L、(26.68±8.94)pg/ml,差异有统计学意义(P<0.05)。观察组不良反应发生率为9.68%,略高于对照组的6.45%,差异无统计学意义(P>0.05)。结论布地奈德及特布他林联合噻托溴铵治疗AECOP患者能够降低炎性因子水平,改善血气指标和肺功能,且安全性高。Objective To investigate the clinical effects of Buddenide and tebutalin and thiatroammonium bromide in patients with acute aggravating chronic obstructive pulmonary disease(AECOPD).Methods 124 elderly patients with acute aggravation period admitted in our hospital from October 2019 to November 2020 were divided into two groups according to randomized digital table,62 each.The control group treated budinnide suspension+tebutalin,and the observation group treated thiatropium bromide powder aerosol.Two groups of lung function,blood gas index,inflammatory factor level and safety levels were compared.Results The 1-second forced breath volume(FEV1),FEV1/forced lung capacity(FVC),arterial oxygen pressure(PaO_(2))were(1.44±0.20)L,(66.24±7.65)%and(83.94±7.62)mmHg,respectively Higher than(1.05±0.17)L,(61.83±7.82)%,(64.52±5.13)mmHg,in the control group Carbon dioxide subpressure(PaCO_(2)),Creactive protein(CRP),interin-6(IL-6)are(42.55±5.11)mmHg,(1.03±0.38)mg/L and(18.17±8.63)pg/ml,mg/L below(54.98±5.13)mmHg,(1.44±0.47),and(26.68±8.94)pg/ml,in the control group The differences is statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 9.68%,slightly higher than 6.45%in the control group,and the difference was not statistically significant(P>0.05).Conclusion Budenide and Tebutalin combined with thiotropium bromide can reduce inflammatory factor level,improve blood gas index and lung function,and have high safety.

关 键 词：慢性阻塞性肺疾病 急性加重期 布地奈德 特布他林 噻托溴铵 

分 类 号：R563.8[医药卫生—呼吸系统]