卡前列甲酯栓联合缩宫素预防足月阴道分娩产妇产后出血的临床价值  

The Value of Carprost Methyl Suppository Combined with Oxytocin in Preventing Postpartum Hemorrhage in Full-term Vaginal Delivery

作　　者：梁爱静 李可可 LIANG Ai-jing;LI Ke-ke(Department of Obstetrics and Gynecology,Mengjin County Maternal and Child Health Hospital,Luoyang 471700 China;Department of Imaging,Luoyang New District People's Hospital,Luoyang 471700 China)

机构地区：[1]河南省孟津县妇幼保健院妇产科,河南孟津471700 [2]洛阳新区人民医院影像科,河南洛阳471700

出　　处：《内蒙古医学杂志》2021年第12期1447-1449,共3页Inner Mongolia Medical Journal

基　　金：河南省自然科学基金项目(编号:LHGJ20191366)。

摘　　要：目的探讨卡前列甲酯栓联合缩宫素预防足月阴道分娩产妇产后出血的临床价值。方法选取2019年3月至2021年3月在本院足月阴道分娩的76例产妇,采用随机分组分为对照组和观察组,各38例。对照组患者常规采用缩宫素,观察组在对照组基础上联合卡前列甲酯栓。观察两组产妇产后2h以及产后24h总出血量。在产前和产后抽取产妇的静脉血,检测产妇的血红蛋白(HGB)和血清一氧化氮(NO)和一氧化氮合酶(NOs)的水平。记录两组治疗期间的不良反应发生情况。结果观察组产妇产后2h及24h的出血量明显少于对照组,两组比较差异具有统计学意义(P<0.05);观察组产后的HGB水平高于对照组,NO、NOs水平小于对照组(P<0.05)。观察组的不良反应发生率为15.79%,和对照组的18.42%比较差异无统计学意义(P>0.05)。结论卡前列甲酯栓联合缩宫素降低产妇的血清NO、NOs水平,可预防产妇产后出血,且安全性好。Objective To explore the value of carboprost methyl suppository combined with oxytocin to prevent postpartum hemorrhage in full-term vaginal delivery women.Methods A total of 76 parturients who delivered full-term vaginal delivery in our hospital from March 2019 to March 2021 were selected and randomly divided into control group and observation group,with 38 cases in each group.Patients in the control group were routinely treated with oxytocin,and the observation group was combined with carboprost methyl suppository on the basis of the control group.The total bleeding volume of the two groups of parturients 2 h and 24 h postpartum was observed.The venous blood of the parturient was taken before and after the delivery,and the levels of hemoglobin(HGB)and serum nitric oxide(NO)and nitric oxide synthase(NOs)of the parturient were tested.The occurrence of adverse reactions during the treatment of the two groups was recorded.Results The postpartum blood loss of the observation group was significantly less than that of the control group at 2 h and 24 h,which was different(P<0.05);the postpartum HGB level of the observation group was higher than that of the control group,and the levels of NO and NOs were lower than the control group(P<0.05).The incidence of adverse reactions in the observation group was 15.79%,which was no difference compared with 18.42%in the control group(P>0.05).Conclusion The combination of carprost methyl suppository and oxytocin can reduce the levels of serum NO and NOs in the parturients,and can prevent the postpartum hemorrhage of the parturients with good safety.

关 键 词：卡前列甲酯栓 缩宫素 足月阴道分娩 产后出血 

分 类 号：R711[医药卫生—妇产科学]