米索前列醇、小剂量催产素用于晚期妊娠引产  

Misoprostol and Low-dose Oxytocin for Induction of Labor in Late Pregnancy

作　　者：罗广华 王晓平[1] 李英琼[1] 骆凤 LUO Guanghua;WANG Xiaoping;LI Yingqiong;LUO Feng(Department of Obstetrics and Gynecology,Huangjiang Hospital of Dongguan City,Dongguan Guangdong 523750,China)

机构地区：[1]东莞市黄江医院妇产科,广东东莞523750

出　　处：《中国卫生标准管理》2021年第22期99-102,共4页China Health Standard Management

摘　　要：目的分析米索前列醇阴道给药及催产素小剂量静点两种方法用于晚期妊娠引产的临床效果。方法选取2017年2月—2019年5月本院妇产科80例行晚期妊娠引产患者进行观察,采用随机数表法将全部患者平均纳入对照组(n=40)与治疗组(n=40),对照组给予催产素小剂量静点治疗,治疗组采用米索前列醇阴道给药进行晚期妊娠引产,比较两组产妇产中、后出血量,不良反应及分娩结局。结果两组出血状况比较,治疗组产中及产后2、24 h出血量均少于对照组,组间差异有统计学意义(P<0.05);两组并发症发生率比较,治疗组明显低于对照组,差异有统计学意义(P<0.05)。两组分娩结局比较,治疗组各观察指标发生率均明显低于对照组(P<0.05)。结论采用米索前列醇阴道给药进行晚期妊娠引产,相比于使用催产素小剂量静点方式,可减少产中和产后出血量,降低产妇不良反应发生率,同时利于改善产妇分娩结局,提升产妇分娩安全性。Objective To analyze the clinical effects of vaginal administration of misoprostol and low-dose intravenous oxytocin for induction of labor in late pregnancy.Methods Selected 80 patients from February 2017 to May 2019 in the department of obstetrics and gynecology in our hospital who underwent late pregnancy induction.The random number table method was used to divided all patients into the control group(n=40)and the treatment group(n=40).The control group was given a small dose of oxytocin intravenously,and the treatment group was given vaginal misoprostol for late pregnancy Induced labor,compared the bleeding volume,adverse reactions and delivery outcomes of the two groups of women during and after delivery.Results Compared the bleeding status between the two groups,the bleeding volume in the treatment group during delivery,2 h and 24 h after delivery was less than those of the control group,and the difference was significant(P<0.05).Compared the incidence of complications between the two groups,the treatment group was significant lower than the control group(P<0.05).Comparing delivery outcomes,the incidence of observed indicators was significantly lower than of the control group(P<0.05).Conclusion The vaginal administration of misoprostol to induce labor in late pregnancy can reduce the amount of intrapartum and postpartum hemorrhage,reduce the incidence of maternal adverse reactions,and improve the outcome of maternal delivery compared with the use of small doses of oxytocin.The safety of maternal delivery improved.

关 键 词：米索前列醇 阴道给药 催产素 小剂量静点 晚期妊娠引产 不良反应 

分 类 号：R714[医药卫生—妇产科学]