晚期早产儿出生时25-羟基维生素D水平异常高危因素及疗效分析  

Analysis of high risk factors and curative effect of abnormal 25-(OH)D levels at birth in late preterm infants

作　　者：王洪波[1] 王燕玲[1] 贺瑞荣[1] 张秋丽[1] 蔡娟[1] 周建生[1] WANG Hong-bo;WANG Yan-ling;HE Rui-rong;ZHANG Qiu-li;CAI Juan;ZHOU Jian-sheng(Department of Pediatrics,First People's Hospital of Shizuishan City,Shizuishan 753200,Ningxia,China)

机构地区：[1]宁夏石嘴山市第一人民医院儿科,宁夏石嘴山753200

出　　处：《中国校医》2021年第11期827-829,共3页Chinese Journal of School Doctor

基　　金：宁夏卫健委科研课题(2019-NW-078)。

摘　　要：目的研究晚期早产儿出生时25羟基维生素D[25-(OH)D]水平异常高危险因素,并观察常规治疗后的效果。方法选取100例于2017年1月—2020年6月在石嘴山市第一人民医院新生儿病室住院的晚期早产儿,根据25-(OH)D水平分为缺乏组(66例)和充足组(34例),采用Logistic回归分析法明确影响晚期早产儿出生时25-(OH)D水平异常的危险因素,对缺乏组予以治疗,观察治疗后的临床效果。结果缺乏组冬春季出生晚期早产儿为90.9%(60/66)高于充足组27.78%(10/34)(χ^(2)=40.413,P<0.001);母亲孕龄为(29.91±4.13)岁,大于充足组的(28.04±4.19)岁、(23.21±3.01)kg/m^(2),(χ^(2)=2.134,P=0.035);母亲体质量指数(BMI)为(26.97±2.57)kg/m^(2),大于充足组的(23.21±3.01)kg/m^(2),(t=6.534,P<0.001)。Logistic回归分析显示,冬春季出生(OR=2.659,95%CI 2.303~3.015,P<0.001)、母亲孕龄(OR=3.425,95%CI 2.064~4.785,P=0.002)、母亲BMI(OR=2.136,95%CI 0.491~3.781,P=0.006)为晚期早产儿在出生时25-(OH)D缺乏的相关高危因素。缺乏组的晚期早产儿3个月龄时25-(OH)D水平为(51.25±3.87)nmol/L,高于出生24 h内(25.31±3.57)nmol/L(t=40.025,P<0.001),且与充足组3个月龄时无明显差异(t=0.992,P=0.324)。结论冬春季出生、母亲孕龄、母亲BMI是影响晚期早产儿25-(OH)D水平的危险因素,经过治疗,早产儿25-(OH)D水平能恢复正常。Objective To study the risk factors of abnormally high 25-hydroxyvitamin D[25-(OH)D]levels at birth in late preterm infants,and observe the effects of the conventional treatment.Methods A total of 100 late preterm infants who were hospitalized in the neonatal ward of Shizuishan First People's Hospital from January 2017 to June 2020 were selected.According to their 25-(OH)D levels,they were divided into a deficiency group(66 cases)and an adequate group(34 cases).By using logistic regression analysis,the risk factors that affect the abnormal 25-(OH)D levels of late preterm infants at birth were clarified,and the deficiency group was treated with the conventional method and the clinical effect was observed after the treatment.Results The proportion(90.9%,60/66)of lateborn premature infants in winter and spring of the deficient group was higher than that(27.78%,10/34)of the adequate group(χ^(2)=40.413,P<0.001);the maternal gestational age[(29.91±4.13)years old]of the deficient group was greater than that[(28.04±4.19)years old]of the sufficient group(χ^(2)=2.134,P=0.035);the maternal body mass index(BMI)[(26.97±2.57)kg/m^(2)]of the deficient group was higher than that[(23.21±3.01)kg/m^(2)]of the sufficient group(t=6.534,P<0.001).Logistic regression analysis showed that birth in winter and spring(OR=2.659,95%CI 2.303-3.015,P<0.001),mother's gestational age(OR=3.425,95%CI 2.064-4.785,P=0.002),mother's BMI(OR=2.136,95%CI 0.491-3.781,P=0.006),and 25-(OH)D deficiency in late preterm infants were related highrisk factors.The 25-(OH)D level[(51.25±3.87)nmol/L]of late preterm infants in the deficiency group at 3 months of age was higher than that[(25.31±3.57)nmol/L]within 24 hours of birth(t=40.025,P<0.001),and compared with the adequate group at 3 months old,there was no significant difference(t=0.992,P=0.32).Conclusion Birth in winter and spring,mother's gestational age,and mother's BMI are risk factors that affect the 25-(OH)D level of late preterm infants.After the treatment,the 25-(OH)D level of preterm infants c

关 键 词：晚期早产儿 25羟基维生素D 危险因素 

分 类 号：R722[医药卫生—儿科]