NR5A2基因的研究进展  

Research progress on NR5A2 gene

作　　者：张云鹏 张琪[2] 高一 刘庆雨[2] 张庆[2] 张净博 张树敏 ZHANG Yunpeng;ZHANG Qi;GAO Yi;LIU Qingyu;ZHANG Qing;ZHANG Jingbo;ZHANG Shumin(College of Animal Science and Technology,Jilin Agricultural University,Changchun 130000,China;Jilin Academy of Agricultural Sciences,Changchun 130000,China;Femas Animal Husbandry Co.,Ltd.,Gongzhuling National Agricultural Science and Technology Park,Gongzhuling 136100,China)

机构地区：[1]吉林农业大学动物科学技术学院,长春130000 [2]吉林省农业科学院,长春130000 [3]公主岭国家农业科技园飞马斯牧业有限公司,吉林公主岭136100

出　　处：《黑龙江畜牧兽医》2021年第23期41-45,共5页Heilongjiang Animal Science And veterinary Medicine

基　　金：吉林省农业科技创新工程项目“吉林黑猪新品种选育及产业开发”(CXGC2021ZD003);吉林省科技厅科技攻关项目“生猪高效繁育与现代化养殖技术开发”(20190301036NY);吉林省科技厅地方科技创新与扶贫项目(20191001039XH);吉林省科技厅重点研发项目“引进长白猪的选育及杂交利用研究”(20210202029NC);吉林省科技发展计划项目(20191001039XH)。

摘　　要：孤儿核受体(NR5A2)基因是NR5A亚家族成员之一,表达于内胚层组织,如性腺、肝脏、胰腺和肠道等,参与机体发育、细胞增殖和肿瘤生成,调节芳香化酶和雌激素代谢酶编码基因的表达。NR5A2基因是卵巢颗粒细胞增殖的关键调节因子,探究其对动物繁殖性能的影响对遗传选育具有重要意义。文章对NR5A2基因结构特征、表达定位、调控机制及生理功能进行了综述,以期为进一步探究NR5A2基因提供参考。NR5 A2, a member of NR5 A subfamily, is expressed in endoderm, such as gonad, liver, pancreas and intestine. NR5 A2 is involved in body development, cell proliferation and tumorigenesis, and regulates the expression of genes encoding aromatase and estrogen metabolizing enzyme. NR5 A2 gene is a key regulator of ovarian granulocyte proliferation. It is of great significance for genetic selection to explore the effect of NR5 A2 gene on reproductive performance. The structural characteristics, expression location, regulatory mechanism and physiological function of NR5 A2 gene were reviewed in this paper, in order to provide reference for further exploration of NR5 A2 gene.

关 键 词：NR5A2基因 繁殖性能 表达定位 调控机制 生理功能 

分 类 号：S814[农业科学—畜牧学]