新型多功能化金纳米棒的合成与表征  

Synthesis and Characterizations of a New Multifunctional Gold Nanorod

作　　者：吴克勤 许海艳 吴远波 彭珊珊 张鸿 张瑜娟[3] Wu Keqin;Xu Haiyan;Wu Yuanbo;Peng Shanshan;Zhang Hong;Zhang Yujuan(Jiangxi Academy of Medical Sciences;Department of Graduare School,Nanchang Jiangxi 330063;Department of Immunology of Basic Medical Science,Nanchang Jiangxi 330063)

机构地区：[1]江西省医学科学院 [2]南昌大学研究生院医学部,江西南昌30063 [3]南昌大学基础医学院免疫教研室,江西南昌30063

出　　处：《江西化工》2021年第6期36-39,共4页Jiangxi Chemical Industry

基　　金：江西省教育厅科学技术研究项目一般项目(GJJ180114)o。

摘　　要：设计合成了一种具有肿瘤靶向、可携带si RNA的新型金纳米棒(Gold nanorod,GNR)纳米靶向系统GNR-MAN。GNR长约30 nm,直径约10 nm。NMR表征显示GNR-MAN制备成功,经修饰后的GNR-MAN未见聚集。带正电荷的MUA-PEI代替CTAB对GNR修饰,可载入带负电的si RNA。由于某些肿瘤细胞、免疫细胞等表面甘露糖受体高表达,末端经甘露糖修饰后的金纳米棒可具有靶向这些细胞的功能。A novel nano system was developed,which could target liver cancer and carry siRNA.The first was a GNR backbone that was about 30 nm in length and 10 nm in diameter.No aggregation of GNRs was observed after chemical conjugation.Secondly,GNR was modified by positively charged MUA-PEI instead of CTAB in order to load negatively charged siRNA.The third functional moiety was the mannose(MAN).Considering the abundant expression of MAN receptors on some cancer cells,we conjugated mannose as a guide adaptor to the nano-carrier GNR-MAN,making it capable of tumor-specific homing.

关 键 词：金纳米棒 甘露糖 

分 类 号：TB383.1[一般工业技术—材料科学与工程] TQ460.1[化学工程—制药化工] TG146.31[金属学及工艺—金属材料]