Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation:a resting-state fMRI study  

作　　者：Ling Ling Wen-Feng Liu Yu Guo Rong-Bin Liang Hui-Ye Shu Li-Juan Zhang Qiu-Yu Li Qian-Min Ge Yi-Cong Pan Yi Shao 

机构地区：[1]Affiliated Eye Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China [2]Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Jiangxi Province Clinical Ophthalmology Institute,Nanchang 330006,Jiangxi Province,China [3]Department of Hepatic Oncology,Zhongshan Hospital,Fudan University,Shanghai 200032,China [4]Department of Radiology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2021年第12期1957-1962,共6页国际眼科杂志（英文版）

基　　金：the National Natural ScienceFoundation (No.82160195);Central Government GuidesLocal Science and Technology Development Foundation(No.20211ZDG02003);Key Research Foundation of JiangxiProvince (No.20181BBG70004;No.20203BBG73059);Excellent Talents Development Project of Jiangxi Province(No.20192BCBL23020).

摘　　要：AIM:To assess changed spontaneous brain activity in hyperthyroid exophthalmos(HE)patients by the amplitude of the low-frequency fluctuation(ALFF)method,and to analyze the correlation between brain activity and ALFF values in these patients.METHODS:Totally 18 HE and 18 hyperthyroid nonexophthalmos(HNE)patients were enrolled.The participants were tested by resting-state functional magnetic resonance imaging,and receiver operating characteristic(ROC)curves were generated to classify the ALFF values of the study population.Pearson’s correlation analysis was utilized to evaluate the relationship between the ALFF values obtained from different brain areas and clinical manifestations.RESULTS:Contrary to HNE patients,we observed lower ALFF values in the left calcarine fissure and surrounding cortex(LCFSC)in HE patients.In the ROC curve analysis of the LCFSC,the area under the curve reflected a high degree of accuracy.In addition,there was positive correlation between mean ALFF values of the LCFSC and the bestcorrected visual acuity of the affected eyes.CONCLUSION:The study displays abnormal brain activity in LCFSC in patients with HE,which might suggest pathological mechanism of visual impairment of HE patients.

关 键 词：hyperthyroid exophthalmos amplitude of low-frequency fluctuation functional magnetic resonance imaging spontaneous brain activity 

分 类 号：R581.1[医药卫生—内分泌] R771.3[医药卫生—内科学]