镁对慢性肾脏病及其主要并发症的作用研究进展  

Role of magnesium in chronic kidney disease complications

作　　者：龙孟团 朱晓宇[1] 魏雪娇 赵丹[1] 姜丽丽[1] 杜玉君[1] Long Meng-tuan;Zhu Xiao-yu;Wei Xue-jiao;Zhao Dan;Jiang Li-li;Du Yu-jun(Department of Nephrology,First Hospital,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院肾病内科,长春130021

出　　处：《临床肾脏病杂志》2021年第12期1033-1040,共8页Journal Of Clinical Nephrology

基　　金：吉林省产业技术研究与开发专项项目(2018C052-9);自然科学基金(学科布局项目)(20190201248JC)。

摘　　要：慢性肾脏病(chronic kidney diseases, CKD)具有发病率高、病死率高等特点,由于肾脏受到不可逆性病理损害,CKD往往进展为慢性肾衰竭和终末期肾病,其后期的治疗给CKD患者带来了极大的身心健康危害和经济负担。CKD往往伴随多个系统疾病的发生,如慢性肾脏病矿物质及骨代谢异常、心血管并发症、神经、肌肉、胃肠道等组织功能异常及贫血。反过来,这些疾病亦会加重CKD的进展。镁为多种酶的辅因子,具有调节能量及矿物质代谢、促进蛋白质合成、抗炎和抗氧化应激作用,镁或许能通过这些效应延缓CKD病程,调节CKD患者多个系统疾病,改善疾病预后。肾脏是调节镁浓度的重要器官,因此有必要理解镁与CKD及其并发症之间的相互作用,为镁在CKD治疗中的应用提供理论基础。Chronic kidney disease(CKD) is characterized by a high incidence rate and a high mortality.And irreversible pathological damage of CKD may progress to chronic renal failure and end-stage kidney disease.Untimely treatment has brought great harms to physical and mental health and economic burdens to patients.And CKD leads also to multiple systemic diseases, such as mineral bone disease, cardiovascular complications, neuropathies, muscular disorders, gastrointestinal dysfunctions and anemia.And these diseases will accelerate the progression of CKD.As a cofactor of many enzymes, magnesium may regulate energy and mineral metabolism, promote protein synthesis and antagonize inflammatory responses and antioxidant stress.Also it is capable of delaying the course of CKD,regulating multiple systemic diseases and improving patient prognosis.Kidney is also a vital regulatory organ of magnesium.Understanding the interactions between magnesium and CKD and its complications may provide theoretical rationales for using magnesium in CKD.

关 键 词：镁 慢性肾脏病 并发症 

分 类 号：R692[医药卫生—泌尿科学]