成骨过程中细胞内能量代谢研究进展  

Research progress of intracellular energy metabolism in the process of osteogenesis

作　　者：叶嘉鹏 王建伟[2] 马勇[1] 张亚峰[2] 张强[1] 张宗瑞 尹恒[1,2] 肖吉日木图 李绍烁 YE Jiapeng;WANG Jianwei;MA Yong;ZHANG Yafeng;ZHANG Qiang;ZHANG Zongrui;YIN Heng;XIAO Jirimutu;LI Shaoshuo(Nanjing University of traditional Chinese medicine,Nanjing 210038,China;Wuxi Affiliated Hospital of Nanjing University of traditional Chinese medicine,Wuxi 214071,China;Inner Mongolia Medical University,Hohhot 010110,China)

机构地区：[1]南京中医药大学,江苏南京210038 [2]南京中医药大学无锡附属医院,江苏无锡214071 [3]内蒙古医科大学,内蒙古自治区呼和浩特010110

出　　处：《中国骨质疏松杂志》2021年第12期1838-1843,共6页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(81873320,81973878);江苏省自然科学基金(BK20180167);江苏中医药领军人才项目(SLJ0218);无锡市“科教强卫工程”青年人才项目(QNRC042);无锡市卫生健康委员会转化医学专项(ZM009);江苏高校护理学优势学科建设工程资助项目(2019YSHL154);2021年江苏省研究生科研创新计划项目(KYCX21-1698)。

摘　　要：骨质疏松症是一种全身性代谢性骨病,是由于破骨细胞介导的骨吸收和成骨细胞介导的骨形成之间失衡引起的。近年来骨骼细胞内能量代谢重新引起人们的兴趣,因为这些过程有可能成为骨质疏松症治疗的靶点。成骨细胞是骨骼重塑单位的骨形成细胞,对骨骼的生长和稳定至关重要。本文拟探讨骨形成过程中骨髓间充质干细胞和成骨细胞等成骨相关细胞的生物能学,主要包含葡萄糖、脂肪酸、氨基酸在成骨过程中分解代谢并产生能量的特点。Osteoporosis is a systemic metabolic bone disease, which is caused by the imbalance between osteoclast mediated bone resorption and osteoblast mediated bone formation. In recent years, the energy metabolism in bone cells has aroused people’s interest again, because these processes may become targets for the treatment of osteoporosis. Osteoblasts are bone forming cells of bone remodeling unit, which are essential for the growth and maintenance of bone. In this paper, we discuss bioenergetics in osteoblast associated cells such as bone marrow mesenchymal stem cells and osteoblasts during bone formation, which mainly including glucose, fatty acids, amino acids catabolism and energy production characteristics in the process of osteogenesis.

关 键 词：骨质疏松症 成骨分化 骨骼形成 能量代谢 

分 类 号：R34[医药卫生—基础医学]