免疫检查点VISTA及其在自身免疫性疾病中作用的研究现状  

Research status of immune checkpoint VISTA and its roles in autoimmune diseases

作　　者：钱宇婧 张美芬(指导)[1] QIAN Yu-Jing;ZHANG Mei-Fen(Department of Ophthalmology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院眼科,北京100730

出　　处：《中国免疫学杂志》2021年第22期2810-2814,共5页Chinese Journal of Immunology

摘　　要：自身免疫性疾病是一类由于机体免疫耐受功能紊乱导致的慢性炎症性疾病,病因不清。T细胞激活抑制物免疫球蛋白可变区结构域(VISTA)是一个新的、独特的负性免疫检查点分子,多数研究认为,VISTA可抑制T淋巴细胞和髓系细胞的活化和功能,在自身免疫性疾病(如系统性红斑狼疮、自身免疫性脑脊髓炎、银屑病、自身免疫性肝炎)的发生发展中具有保护作用,并可作为十分有效的潜在免疫治疗靶点。本文将对VISTA及其在自身免疫性疾病中的作用研究进展做一综述。Autoimmune disease is a wide range of chronic inflammatory diseases caused by immune tolerance disorders,resulting in severe damage to multiple organs and systems.V-domain Ig suppressor of T cell activation(VISTA)is a novel and unique negative immune checkpoint molecule.Most recent studies have found that VISTA plays protective roles in the development of several autoimmune diseases(i.e.systemic lupus erythematosus,autoimmune encephalomyelitis,psoriasis and autoimmune hepatitis)via inhibiting the activation and function of T lymphocytes and myeloid cells,and could serve as an effective potential immunotherapy target.This article will summarize the research status of VISTA and its roles in autoimmune diseases.

关 键 词：T细胞激活抑制物免疫球蛋白可变区结构域 自身免疫性疾病 免疫检查点 综述 

分 类 号：R392.9[医药卫生—免疫学]