mTOR/Akt信号通路在急性胰腺炎炎症反应中作用机制的研究进展  

Study on the mechanism of mTOR/Akt signaling pathway in acute pancreatitis inflammatory response

作　　者：杜琳敏 王尧[2] DU Linmin;WANG Yao(Department of Gastroenterology,Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou 550003,China;Guizhou Medical University,Guiyang,Guizhou 550003,China)

机构地区：[1]贵州医科大学附属医院消化内科,贵州贵阳550003 [2]贵州医科大学,贵州贵阳550003

出　　处：《医药前沿》2021年第34期15-17,共3页Journal of Frontiers of Medicine

摘　　要：急性胰腺炎(AP)是一种全身炎症性疾病,其中胰腺腺泡的损伤对AP的发展及预后起重要作用。mTOR/Akt信号通路可通过增加细胞自噬、降低细胞凋亡,加重胰腺损伤。该文章查阅近年来国内外研究资料,综述mTOR/Akt信号通路在急性胰腺炎炎症反应中作用机制。Acute pancreatitis(AP)is a systemic inflammatory disease,and the injury of pancreatic acini plays an important role in the development and prognosis of AP.The mTOR/Akt signaling pathway can increase autophagy,reduce apoptosis,and aggravate pancreatic injury.In this paper,the mechanism of mTOR/Akt signaling pathway in acute pancreatitis inflammatory response was reviewed by referring to domestic and foreign research data in recent years.

关 键 词：急性胰腺炎 mTOR/Akt信号通路 炎症 凋亡 自噬 

分 类 号：R657.5[医药卫生—外科学]