丙种球蛋白佐治小儿重症支原体肺炎疗效分析  

Analysis of the Therapeutic Effect of Gamma Globulin in the Treatment of Severe Mycoplasma Pneumonia in Children

作　　者：侯丽丽 黄良锦[1] 曹建伟[1] 郑铠军[1] HOU Li-li;HUANG Liang-jin;CAO Jian-wei;ZHENG Kai-jun(Zhongshan People's Hospital,Guangdong Zhongshan 528400)

机构地区：[1]中山市人民医院,广东中山528400

出　　处：《深圳中西医结合杂志》2021年第19期145-147,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨丙种球蛋白佐治小儿重症肺炎支原体肺炎(SMPP)的效果。方法:选取中山市人民医院2018年12月至2019年12月收治的120例SMPP患儿,随机分为对照组和观察组,各60例,对照组给予阿奇霉素治疗,观察组在对照组基础上使用丙种球蛋白佐治。比较两组患儿临床疗效、症状改善时间、肺功能指标。结果:观察组患儿临床治疗有效率为93.33%,高于对照组的80.00%,差异具有统计学意义(P<0.05);观察组患儿退热时间、肺部啰音消失时间、止咳时间均短于对照组,差异具有统计学意义(P<0.05);治疗后,两组患儿第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC水平均较治疗前升高,且观察组高于对照组,差异具有统计学意义(P<0.05)。结论:丙种球蛋白佐治SMPP的临床效果显著,可以缩短患儿恢复时间,有效改善患儿肺功能。Objective To explore the effect of gamma globulin in the treatment of severe mycoplasma pneumoniae pneumonia(SMPP)in children.Methods A total of 120 children with SMPP admitted to Zhongshan People’s Hospital from December 2018 to December 2019 were randomly divided into a control group(60 cases)and an observation group(60 cases).The control group was treated with azithromycin and the observation group was treated with gamma globulin on the basis of the control group.The clinical efficacy,time of symptom improvement,and lung function indexes were compared between the two groups of children.Results The effective rate of clinical treatment in children in the observation group was 93.33%,which was higher than 80.00%in the control group.The difference was statistically significant(P<0.05);Time of fever regression,lung rale disappearance time,and cough stop time were all were shorter than those of the control group,and the differences were statistically significant(P<0.05);After treatment,the two groups of children increased their forced expiratory volume(FEV1),forced vital capacity(FVC),and FEV1/FVC in the first second compared to those before treatment,and the lung function indexes in the observation group is higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Gamma globulin has a significant clinical effect in adjuvant SMPP,which can shorten the recovery time of children and effectively improve the lung function of children.

关 键 词：重症肺炎支原体肺炎 丙种球蛋白 阿奇霉素 儿童 

分 类 号：R725.6[医药卫生—儿科]