超声联合微泡开放血脑屏障的研究进展  

Research progress of ultrasound combined with microbubbles to open the blood-brain barrier

作　　者：钟林宏 祝兴宇 张渝[1] 杨远梅 陈东鸿 王玉琦 云旦次仁 李攀[2] ZHONG Linhong;ZHU Xingyu;ZHANG Yu;YANG Yuanmei;CHEN Donghong;WANG Yuqi;YUNDAN Ciren;LI Pan(Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学,重庆市400016 [2]重庆医科大学附属第二医院超声科

出　　处：《临床超声医学杂志》2021年第12期934-937,共4页Journal of Clinical Ultrasound in Medicine

基　　金：国家自然科学基金项目(81971633);重庆医科大学大学生科学研究与创新实验项目(SRIEP202006)。

摘　　要：超声联合载药微泡靶向运输技术开放血脑屏障可提高颅内特定区域的药物浓度,从而发挥药物治疗作用。超声作用下的微泡会产生空化效应,打开内皮细胞间的紧密连接,随着血脑屏障的开放,载药微泡可靶向传递至颅内特定部位。但以微泡为载体的超声靶向微泡运输技术会因超声强度、辐射时间、微泡材料及剂量大小等因素影响血脑屏障开放的程度及安全性,合理运用超声技术开放血脑屏障并减少其对脑组织的损伤,有助于提高脑部疾病的微泡靶向治疗效果。本文就超声联合微泡开放血脑屏障的方法、安全性评估及防控对策进行综述。Opening the blood-brain barrier by ultrasound combined with drug-loaded microbubble targeted transport technology can increase the local drug concentration in the brain,so as to better play its pharmacodynamic effect and have a better therapeutic effect on brain diseases.Microbubbles under the action of ultrasound will produce a cavitation effect.With the opening of the blood-brain barrier,the tight junctions between endothelial cells are opened,and drug-loaded microbubbles formed by drugs and microbubbles can be delivered to specific parts of the brain.However,the ultrasound-targeted microbubble transport technology using microbubbles as a carrier is not completely non-invasive.Parameters such as ultrasound intensity,radiation time,microbubble material and dose will affect the opening degree and safety of blood-brain barrier,so it is reasonable to open blood-brain barrier and reducing technical damage are very important for the effect and prognosis of microbubble targeted therapy for brain diseases.This paper reviews the method,safety evaluation,prevention and control measurement of opening blood-brain barrier by ultrasound combined with microbubbles.

关 键 词：超声 微泡 血脑屏障 安全性 

分 类 号：R445.1[医药卫生—影像医学与核医学]