D-最优混料设计优化实脾消水凝胶贴膏的处方  

Application of D-optimal Mixture Experimental Design Method to Optimizing the Formulation of Shipi Xiaoshui Gel Plaster

作　　者：李栋[1] 唐永和[1] 王海洋[1] 梁莹莹[1] 张淑君[1] 赫军[1] 马秉智[1] Li Dong;Tang Yonghe;Wang Haiyang;Liang Yingying;Zhang Shujun;He Jun;Ma Bingzhi(Department of Pharmacy,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院药学部,北京100029

出　　处：《中国药师》2021年第12期2249-2252,2292,共5页China Pharmacist

基　　金：中日友好医院2018年院级科研基金资助项目(编号:2017-2-QN-14)。

摘　　要：目的:将实脾消水浸膏改制成实脾消水凝胶贴膏。方法:在单因素试验的基础上,以聚丙烯酸钠NP700、甘氨酸铝、酒石酸、甘油、聚乙烯基吡咯烷酮90F、纯化水为考察因素,以初黏力、剥离强度及胶强度为评价指标,采用D-最优混料设计筛选出实脾消水凝胶贴膏最优处方。结果:实脾消水凝胶贴膏的最优配方:聚丙烯酸钠NP700 5 g、甘氨酸铝0.3 g、酒石酸0.3 g、甘油35 g、聚乙烯基吡咯烷酮90F 5 g、纯化水36.4 g,药液18 g。结论:优选出的基质黏附力适中,膏体性状、皮肤追随性均较好,制备工艺稳定可行,可用于实脾消水凝胶贴膏的制备。Objective: To transform Shipi Xiaoshui extract into Shipi Xiaoshui gel plaster(SXGP).Methods: On the basis of single factor experiment, sodium polyacrylate NP 700,aluminum glycinate, tartaric acid, glycerol, polyvinylpyrrolidone 90 F and purified water were taken as the factors along with adhesive force, peeling strength and gel strength as the evaluation indexes. The D-optimal mixture experimental design was used to optimize the formulation of SXGP. Results: The optimized prescription of SXGP was as follows: sodium polyacrylate NP700 5 g, aluminum glycinate 0.3 g, tartaric acid 0.3 g, glycerol 35 g, polyvinylpyrrolidone 90 F 5 g, purified water 36.4 g, medicine 18 g. Conclusion: The optimized matrix has good adhesive force, the paste has good formulation and skin following, and the preparation process is stable and feasible, which can be used to prepare SXGP.

关 键 词：实脾消水凝胶贴膏 D-最优混料设计 实脾消水浸膏 

分 类 号：R283.6[医药卫生—中药学]