淫羊藿苷干粉吸入剂所选装置的计算模拟和实验验证  

Simulation and experimental verification of selected device for icariin dry powder inhalation

作　　者：周扬[1] 张镓玥 孙峰 王慧芳[1] 曾峰 钟其新 ZHOU Yang;ZHANG Jia-yue;SUN Feng;WANG Hui-fang;ZENG Feng;ZHONG Qi-xin(Suzhou Key Laboratory of Medical Biotechnology,Suzhou Vocational Health College,Suzhou Jiangsu,215009,China;Shenzhen Hospital,Guangzhou University of Chinese Medicine,Shenzhen,Guangdong 518034,China;Artemisinin Research Center,Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510445,China;First Affiliated Hospital,Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510405,China;First Clinical Medical School,Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510405,China)

机构地区：[1]苏州卫生职业技术学院,苏州检验医学生物技术重点实验室,江苏苏州215009 [2]广州中医药大学深圳医院(福田),广东深圳518034 [3]广州中医药大学青蒿研究中心,广东广州510445 [4]广州中医药大学第一附属医院,广东广州510405 [5]广州中医药大学第一临床医学院,广东广州510405

出　　处：《时珍国医国药》2021年第10期2413-2416,共4页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金青年基金(31901002);江苏省卫生健康委医学科研项目(Z2019051);江苏省苏州市科技局民生科技项目(SYSD2018072);2019年福田区卫生公益科研项目(FTWS2019024);2020年福田区卫生公益科研项目(FTWS2020050);2020年江苏省高等学校自然科学面上项目(20KJB360012);2021年江苏省高校“青蓝工程”优秀青年骨干教师培养项目。

摘　　要：目的采用计算流体动力学(CFD)进行药物微粒在淫羊藿苷微粉所用两种装置内部的运动情况模拟,并与体外沉积结果进行对比,验证该结果的准确性。方法采用新一代药用撞击器(NGI)进行体外沉积实验,同时进行CFD模拟实验,深入剖析药物微粒在装置流场的运动状态,对两种装置的颗粒逸出率进行评估。然后将两种实验结果进行对比,验证模拟结果。结果体外沉积实验结果表明长吸嘴刺破型装置优于短吸嘴刺破型装置,模拟结果表明长吸嘴刺破型装置的颗粒逸出率高于短吸嘴刺破型装置。结论采用CFD进行药物微粒在干粉吸入装置中运动情况的模拟,得到的结果较为直观,与体外沉积实验结果相一致,可以很好地预测药物微粒在干粉吸入装置中的运动状况,优选长吸嘴刺破型装置。Objective Computational fluid dynamics(CFD)was used to simulate the movement of drug particles in the two devices used for icariin powder,and the results were compared with the in vitro deposition results to verify the accuracy of the results.Methods NGI device was used for in vitro deposition experiment,and CFD simulation experiment was carried out to analyze the movement state of drug particles in the device flow field,and evaluate the particle escape rate of the two devices.Then the two experimental results were compared to verify the simulation results.Results In vitro deposition experiments showed that the long nozzle puncture device(Osmohaler(1))was better than the short nozzle puncture device(Osmohaler(2)),and the simulation results showed that the particle escape rate of Osmohaler(1)device was higher than that of Osmohaler(2)device.Conclusion The results using CFD to simulate the movement of drug particles in the dry powder inhalation device are more intuitive and consistent with the results of in vitro deposition experiment,which can well predict the movement of drug particles in the dry powder inhalation device,and optimize the long nozzle puncture device.

关 键 词：肺部疾病 淫羊藿苷微粉 干粉吸入剂 刺破型装置 计算模拟 

分 类 号：R283[医药卫生—中药学]