利多卡因凝胶贴膏联合盐酸曲马多缓释片在PHN中的应用  

Application of Lidocaine Cataplasm Combined with Tramadol Hydrochloride Sustained-Release Tablets in PHN

作　　者：盛志锋 张爱萍[1] 邹鲁[1] 许旭东[1] Sheng Zhifeng;Zhang Aiping;Zou Lu;Xu Xudong(Department of Anesthesiology,Changzhou Hospital of Traditional Chinese Medicine,Changzhou 213000,China)

机构地区：[1]常州市中医医院麻醉科,江苏常州213000

出　　处：《巴楚医学》2021年第4期50-53,共4页Bachu Medical Journal

基　　金：江苏省高校哲学社会科学基金(No:2017SJB0273)。

摘　　要：目的:评估利多卡因凝胶贴膏联合盐酸曲马多缓释片在带状疱疹后神经痛(PHN)中的应用效果。方法:选取2018年2月-2021年2月我院收治的80例PHN患者,采用简单随机分组法将患者分为观察组和对照组,每组各40例。对照组采用普瑞巴林联合盐酸曲马多缓释片治疗,观察组采用利多卡因凝胶贴膏联合盐酸曲马多缓释片治疗,均持续治疗1个月。评估患者治疗的临床疗效、睡眠质量和疼痛程度,并记录患者治疗期间不良反应的发生率。结果:治疗后,观察组总有效率为90.00%,与对照组的75.00%相比,差异无统计学意义(P>0.05)。治疗15天和1个月后,观察组的匹茨堡睡眠质量指数量表(PSQI)评分和视觉模拟(VAS)评分均显著低于对照组(均P<0.05)。观察组治疗期间不良反应的发生率为10.00%,与对照组的22.50%相比,差异无统计学意义(P>0.05)。结论:利多卡因凝胶贴膏联合盐酸曲马多缓释片治疗PHN的疗效确切,可改善患者的睡眠质量。Objective:To explore the effects of lidocaine cataplasm combined with tramadol hydrochloride sustained-release tablets in post-herpetic neuralgia(PHN).Methods:A total of 80 patients with PHN in our hospital between February 2018 and February 2021 were enrolled.According to simple random grouping method,they were divided into the observation group and the control group,with 40 cases in each group.Patients in the control group were treated with pregabalin combined with tramadol hydrochloride sustained-release tablets,while the observation group were treated with lidocaine cataplasm combined with tramadol hydrochloride sustained-release tablets.Both groups were continuously treated for 1 month.The clinical curative efficacy,sleep quality and pain degree were evaluated.The incidence of adverse reactions during treatment was recorded.Results:There was no significant difference in total response rate between the observation group and the control group(90.00%Vs 75.00%,P>0.05).After 15 days and 1 month of treatment,scores of Pittsburgh sleep quality index(PSQI)and visual analogue scale(VAS)in the observation group were significantly lower than those in the control group(both P<0.05).There was no significant difference in the incidence of adverse reactions during treatment between these two groups(10.00%Vs 22.50%,P>0.05).Conclusion:Lidocaine cataplasm combined with tramadol hydrochloride sustained-release tablets is effective in the treatment of PHN,which can improve sleep quality of patients.

关 键 词：利多卡因凝胶贴膏 盐酸曲马多缓释片 带状疱疹后神经痛 睡眠质量 

分 类 号：R751[医药卫生—皮肤病学与性病学]