Phthalide-derived oxaspiroangelioic acids A–C with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head  

作　　者：Youzhe Chen Chengbo Xu Weiping Wang Xiaoliang Wang Qinglan Guo Jiangong Shi 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

出　　处：《Chinese Chemical Letters》2021年第10期3257-3260,共4页中国化学快报（英文版）

基　　金：Financial support from the National Natural Sciences Foundation of China (No.81630094);CAMS Innovation Fund for Medical Science (No.2017-I2M-3-010, China);The Drug Innovation Major Project (Nos.2018ZX09711001-004 and 2018ZX09711001-001, China)。

摘　　要：Three phthalide-derived analogues,oxaspiroangelioic acids A–C(1–3),were isolated as minor components of an aqueous extract of the Angelica sinensis root heads(guitou).Oxaspiroangelioic acids A and B were racemates separated into enantiomers by chiral HPLC.Their structures including absolute configurations were determined by spectroscopic data analysis,single crystal X-ray diffraction,exciton chirality method [7_(T)D$IF]and electronic circular dichroism(ECD) calculation.These compounds share an undescribed carbon skeleton,for which biosynthetic pathways are proposed.Compound 1 and its enantiomers showed almost identical activity inhibiting Tandem of P domains in a weak inwardly rectifying K^(+)channel 1(TREK-1).

关 键 词：UMBELLIFERAE Angelica sinensis Phthalide-derived analogues Oxaspiroangelioic acids A–C 

分 类 号：TQ28[化学工程—有机化工]