甲泼尼龙辅助治疗对支原体肺炎患儿疗效及肺功能的影响  

Effect of methylprednisolone adjuvant therapy on children with mycoplasma pneumonia and Pulmonary function

作　　者：何宜 许丽琴[1] 齐旭升[1] HE Yi;XU Li-qin;QI Xu-sheng(Department of Pediatrics,Taihe Hospital,Shiyan 442000,Hubei,China)

机构地区：[1]十堰市太和医院儿科,湖北十堰442000

出　　处：《川北医学院学报》2021年第12期1581-1583,共3页Journal of North Sichuan Medical College

基　　金：湖北省卫生厅科研项目(16092543)。

摘　　要：目的:探讨在支原体肺炎患儿治疗过程中加用甲泼尼的临床效果,并了解肺功能变化。方法:将112例肺炎支原体肺炎(MPP)患儿按不同治疗方式分为观察组与对照组,每组各56例。对照组患儿在营养支持、纠正水、电解质紊乱、化痰、退热、止咳、吸氧等一般治疗的基础上加用阿奇霉素静脉滴注治疗;观察组加用甲泼尼龙,疗程均为3 d。3 d后对治疗效果、肺功能、不良反应进行对比分析。结果:观察组患儿治疗总有效率优于对照组(92.5%vs.71.4%)(P<0.05);观察组患儿体温恢复正常时间、咳嗽及肺部啰音消失时间短于对照组(P<0.05)。治疗前,两组患儿第1秒用力呼气容积(FEV1)、用力肺活量(FVC)比较无统计学差异(P>0.05);治疗后均明显改善(P<0.05),且观察组优于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:小儿支原体肺炎治疗过程中加用甲泼尼龙,可有效提高临床治疗效果,更快地控制临床症状、体征,同时对于患儿肺功能的改善也具有良好的促进作用,且不增加不良反应发生率。Objective:To explore the clinical effect of methylprednisolone in the treatment of children with mycoplasma pneumonia,and to understand the effect of this treatment on children s lung function.Methods:112 children with MPP were divided into the observation and control group according to different treatment method,with 56 cases in each group.The control group were treated with azithromycin intravenous drip on the basis of general treatment such as nutritional support,correction of water,electrolyte disorders,resolving phlegm,relieving fever,relieving cough and oxygen inhalation,methylprednisolone was added in observation group.The treatment course was 3 days.After 3 days,the therapeutic effect,pulmonary function and adverse reactions were contrasted.Results:Compared with the control group,the efficiency rate was higher in the observation group(92.5%vs.71.4%,P<0.05).Compared to the control group,the recovery time of body temperature and the disappearance time of cough and pulmonary rales in the observation group were shorter than those in the control group(P<0.05).Before treatment,there was no significant difference in the first second forced expiratory volume(FEV1)and forced vital capacity(FVC)between the two groups(P>0.05).After the treatment,they were significantly improved(P<0.05),and the observation group was better than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Methylprednisolone in the treatment of children with mycoplasma pneumonia can effectively improve the clinical treatment effect,control clinical symptoms and signs faster,and promote the pulmonary function improvement,adverse reactions incidence was not increased.

关 键 词：支原体肺炎 甲泼尼龙 临床疗效 肺功能 小儿 

分 类 号：R725.6[医药卫生—儿科]