细菌性阴道病与HPV感染、宫颈癌前上皮内瘤变及宫颈浸润癌相关性的研究进展  

Correlation between bacterial vaginosis and continuous HPV infection resulting in CIN and cervical cancer

作　　者：王升科[1] 王冬冬[1] 赵福杰[1] WANG Sheng-ke;WANG Dong-dong;ZHAO Fu-jie(The Affiliated Shengjing Hospital of China Medical University,Shenyang,Liaoning 110004,China;不详)

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004

出　　处：《中国微生态学杂志》2021年第11期1358-1361,共4页Chinese Journal of Microecology

基　　金：国家自然科学基金青年基金(81302271)。

摘　　要：细菌性阴道病(bacterial vaginosis,BV)可以通过破坏机体的免疫调节作用使HPV在宫颈组织中持续感染,导致宫颈癌前上皮内瘤变(cervical intraepithelial neoplasia,CIN)和宫颈癌。同时对BV的诊断可以作为预测CIN发展和宫颈癌发生的生物预测方法,对BV的诊断除了传统的Amsel标准和Nugent评分外,还可通过16SrRNA高通量测序、探针检测和实时PCR等新的分子生物学方法来精确诊断。应用益生菌治疗菌群失调的同时可以预防CIN的发展和宫颈癌的发生,因此通过改善菌群失调来调节机体对HPV病毒的免疫反应可能成为治疗CIN和宫颈癌的新方法。Bacterial vaginosis(BV)is associated with premalignant cervical intraepithelial neoplasia(CIN)and cervical cancer by causing persistent HPV infection through immunoregulation.BV can be regarded as the diagnostic biomarker for CIN and cervical cancer.Except for Amsel standard and Nugent scores,16SrRNA,high-throughput sequencing,direct probe assays,and real-time PCR are used to diagnose BV and evaluate the progression of CIN or cervical cancer.Probiotics can prevent the development of cervical intraepithelial neoplasia and the occurrence of cervical cancer.Therefore,regulation of immune response to HPV by improving floral imbalance may become a new strategy for the treatment of CIN and cervical cancer.

关 键 词：细菌性阴道病 HPV感染 宫颈癌前上皮内瘤变 宫颈癌 益生菌 

分 类 号：R382.21[医药卫生—医学寄生虫学]