大麻素1型受体正电子发射断层显像在神经精神疾病中的应用进展  

Progress on the application of positron emission tomography imaging of cannabinoid type 1 receptor in neuropsychiatric diseases

作　　者：马丽娟 吴爽[1] 张凯 田梅[1] 张宏[1,3,4] MA Lijuan;WU Shuang;ZHANG Kai;TIAN Mei;ZHANG Hong(Department of Nuclear Medicine,the Second Affiliated Hospital,Zhejiang University School of Medicine,Zhejiang University Medical PET Center,Key Laboratory qf Medical Molecular Imaging of Zhejiang Province,Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University,Hangzhou 310009,China;Laboratory for Pathophysiological and Health Science,RIKEN Center for Biosystems Dynamics Research,Kobe 650-0047,Japan;Key Laboratory far Biomedical Engineering of Ministry qf Education,Zhejiang University,Hangzhou 310027,China;College of Biomedical Engineering and Instrument Science,Zhejiang University,Hangzhou 310027,China)

机构地区：[1]浙江大学医学院附属第二医院核医学科,浙江大学医学PET中心,浙江省医学分子影像重点实验室,浙江大学核医学与分子影像研究所,浙江杭州310009 [2]日本理化学研究所生命机能研究中心健康与病态科学研究室,日本神户650-0047 [3]浙江大学生物医学工程教育部重点实验室,浙江杭州310027 [4]浙江大学生物医学工程与仪器科学学院,浙江杭州310027

出　　处：《浙江大学学报（医学版）》2021年第5期666-673,共8页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金(81725009,82030049,32027802)。

摘　　要：大麻素1型受体(CB1R)作为内源性大麻素系统的主要成员,是中枢神经系统表达最丰富的受体之一。CB1R主要分布在突触前神经元的轴突末梢,参与神经元兴奋性及突触可塑性调节,在多种神经精神疾病的致病机制中发挥着重要作用。近年来CB1R放射性配体的不断研发及正电子发射断层成像(PET)等分子影像技术的日渐成熟,有助于实现CB1R在中枢神经系统中表达与分布的在体可视化。目前,CB1RPET显像可以有效评估亨廷顿病及精神分裂症等神经精神疾病患者体内的CB1R水平变化及其与病情严重程度之间的联系,从而为神经精神疾病诊治提供新的见解。本文就CB1RPET显像在阿尔茨海默病、帕金森病、亨廷顿病、精神分裂症、创伤后应激障碍、大麻使用障碍及抑郁症中的应用进展进行综述。Cannabinoid type 1 receptor(CB1R), as the major member of the endocannabinoid system, is among the most abundant receptors expressed in the central nervous system. CB1 R is mainly located on the axon terminals of presynaptic neurons and participate in the modulation of neuronal excitability and synaptic plasticity, playing an important role in the pathogenesis of various neuropsychiatric diseases. In recent years,the consistent development of CB1 R radioligands and the maturity of molecular imaging techniques, particularly positron emission tomography(PET) may help to visualize the expression and distribution of CB1 R in central nervous systemin vivo. At present, CB1R PET imaging can effectively evaluate the changes of CB1 R levels in neuropsychiatric diseases such as Huntington’s disease and schizophrenia, and its correlation with the disease severity, therefore providing new insights for the diagnosis and treatment of neuropsychiatric diseases. This article reviews the application of CB1 R PET imaging in Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, schizophrenia, posttraumatic stress disorder, cannabis use disorder and depression.

关 键 词：大麻素1型受体 正电子发射断层成像 神经退行性变性疾病 精神疾病 精神分裂症 综述 

分 类 号：R445[医药卫生—影像医学与核医学] R74[医药卫生—诊断学]