Construction and imaging of a neurovascular unit model  

作　　者：Taiwei Dong Min Li Feng Gao Peifeng Wei Jian Wang 

机构地区：[1]College of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi Province,China [2]College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan Provinve,China

出　　处：《Neural Regeneration Research》2022年第8期1685-1694,共10页中国神经再生研究（英文版）

基　　金：financially supported by the National Natural Science Foundation of China,Nos.82104412(to TD),81873023(to JW);Natural Science Basic Research Program of Shaanxi Province of China,No.2020JQ-865(to TD);Education Department of Shaanxi Province of China,No.20JK0597(to TD);the Subject Innovation Team of Shaanxi University of Chinese Medicine of China,No.2019-QN02(to PW).

摘　　要：In 2001,the concept of the neurovascular unit was introduced at the Stroke Progress Review Group meeting.The neurovascular unit is an important element of the health and disease status of blood vessels and nerves in the central nervous system.Since then,the neurovascular unit has attracted increasing interest from research teams,who have contributed greatly to the prevention,treatment,and prognosis of stroke and neurodegenerative diseases.However,additional research is needed to establish an efficient,low-cost,and low-energy in vitro model of the neurovascular unit,as well as enable noninvasive observation of neurovascular units in vivo and in vitro.In this review,we first summarize the composition of neurovascular units,then investigate the efficacy of different types of stem cells and cell culture methods in the construction of neurovascular unit models,and finally assess the progress of imaging methods used to observe neurovascular units in recent years and their positive role in the monitoring and investigation of the mechanisms of a variety of central nervous system diseases.

关 键 词：3D printing blood-brain barrier computational biology ENCEPHALOPATHY imaging techniques microfluidic on-chip methods nerve cell co-culture neurovascular unit REVIEW stem cells 

分 类 号：R741[医药卫生—神经病学与精神病学] R-33[医药卫生—临床医学]