基于共价有机框架的仿生光动力学治疗试剂的构建  

Construction of COF-based biomimetic photodynamic therapy reagent

作　　者：叶佳琳 谢辉 黎婧怡 吕敏 陈楠 YE Jialin;XIE Hui;LI Jingyi;LYU Min;CHEN Nan(College of Chemistry and Materials Science,Shanghai Normal University,Shanghai 200234,China)

机构地区：[1]上海师范大学化学与材料科学学院,上海200234

出　　处：《上海师范大学学报（自然科学版）》2021年第6期679-687,共9页Journal of Shanghai Normal University(Natural Sciences)

基　　金：国家自然科学基金(31771102,21974089,31971310)。

摘　　要：共价有机框架(COF)是一类新兴的多孔有机聚合物,因其具有较大的比表面积、有序的孔道结构以及良好的生物相容性,已成为具有潜力的纳米药物载体.制备了基于COF纳米颗粒的仿生纳米复合物,负载光敏剂孟加拉玫瑰红(RB),并包裹癌细胞膜(CMV)对该复合物进行仿生修饰.结果表明:制备的COF/RB@CMV纳米复合物具有良好的生物兼容性,能够被肿瘤细胞有效摄取,并在光照激活条件下产生对细胞具有高毒性的活性氧化物(ROS),进而起到了杀伤肿瘤细胞的作用.提出了一种新的基于COF的仿生纳米平台用作光动力学治疗(PDT)试剂.Covalent organic frameworks(COF)are a new type of porous covalent organic structures that are potential candidates as nanocarriers due to their large specific surface area,ordered pore structure,and good biocompatibility.In the present work,a COF-based biomimetic nanocomposite was prepared.The photosensitizer Rose Bengal(RB)was loaded on the surface of COF,and cancer cell membrane(CMV)was coated to modify the nanoparticles.Our results showed that the synthesized COF/RB@CMV nanocomposite has good biocompatibility,can be efficiently uptaken by tumor cells,and produce highly toxic ralative oxygen species(ROS)under the light activation,which play a role in killing tumor cells.This study provides a new COF-based biomimetic nanoplatform for effective photodynamic therapy(PDT).

关 键 词：共价有机骨架 光动力学支疗(PDT)法 癌细胞膜(CMV) 纳米递送 

分 类 号：Q26[生物学—细胞生物学]