间充质干细胞复合多孔钽治疗骨关节炎的研究进展  

Research advances in mesenchymal stem cells for treatment of osteoarthritis

作　　者：李思雨 刘凯楠 王思涵 李粤源 崔逸爽 王茜 LI Siyu;LIU Kainan;WANG Sihan;LI Yueyuan;CUI Yishuang;WANG Qian(College of Public Health,Clinical School of Medicine North China University of Science and Technology,Tangshan 063200,Heibei Province,China;School of Basic Medicine Science,Clinical School of Medicine North China University of Science and Technology,Tangshan 063200,Heibei Province,China;Hebei Provincial Key Laboratory of Medical-Industrial Integration Precision Medicine,Clinical School of Medicine North China University of Science and Technology,Tangshan 063200,Heibei Province,China)

机构地区：[1]华北理工大学公共卫生学院,河北唐山063200 [2]华北理工大学基础医学院,河北唐山063200 [3]华北理工大学临床医学院,河北唐山063200

出　　处：《解放军医学院学报》2021年第10期1100-1104,共5页Academic Journal of Chinese PLA Medical School

基　　金：国家科技部科技支撑课题资助项目(2012BAE06B03);河北省科技支撑资助项目(16277776D);河北省医学科学研究重点课题计划(20180733);华北理工大学大学生创新创业训练计划(No.X2021180)。

摘　　要：骨关节炎(osteoarthritis,OA)通常以关节透明软骨结构和功能的损伤、进行性退化的方式开始,进而影响所有关节结构。目前临床对其主要采取保守治疗缓解症状,症状严重时手术干预,但仍具有一定局限性和风险性。如今,组织工程学已广泛应用于关节软骨缺损的修复,并取得一定的进展。本文主要综述间充质干细胞以及金属材料多孔钽通过修复软骨缺损治疗OA的研究进展。Osteoarthritis often begins with damage and progressive degradation of articular hyaline cartilage structure and function,and then eventually involves all joint structures.At present,conservative treatment is mainly used to relieve symptoms,while surgical intervention is used when symptoms are serious,but these strategies still have some limitations and risks.Nowadays,tissue engineering has been widely used in the repair of articular cartilage defects and has made progress to a certain extent.This article mainly reviews the research advances in mesenchymal stem cells and porous tantalum in the treatment of osteoarthritis.

关 键 词：骨关节炎 间充质干细胞 多孔金属钽 组织工程学 软骨缺损修复 

分 类 号：R310[医药卫生—基础医学]