泛素化修饰功能在调节动物炎症机制中的研究进展  

Research Advance of Ubiquitination Modification Function in Regulating Animal Inflammation Mechanism

作　　者：牛慧 童津津 熊本海[2] 蒋林树 NIU Hui;TONG Jinjin;XIONG Benhai;JIANG Linshu(Beijing Key Laboratory of Cow Nutrition,College of Animal Science and Technology,Beijing University of Agriculture,Beijing 102206,China;Beijing Institute of Animal Husbandry and Veterinary Sciences,Chinese Academy of Agricultural Sciences,Beijing 100193,China)

机构地区：[1]北京农学院动物科学技术学院,奶牛营养学北京市重点实验室,北京102206 [2]中国农业科学院北京畜牧兽医研究所,北京100193

出　　处：《动物营养学报》2021年第12期6684-6689,共6页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：北京市教委重点项目(20JF0008);国家自然科学基金(31802091)。

摘　　要：泛素化修饰是一种重要的蛋白质翻译后修饰,已经成为调节炎症信号转导等不同生物过程中信号转导的重要机制,并且与动物机体的炎症疾病息息相关。核转录因子-κB(NF-κB)和NLRP3炎性小体是2个典型的炎症反应分子驱动因子,而泛素化修饰在NF-κB和NLRP3炎性小体激活中发挥着不可替代的作用。因此,本文重点讨论了病原体、炎性因子和自由基激活NF-κB中的泛素化调节作用,以及NLRP3炎性小体激活中的泛素化调节作用,旨在为调控机体的炎症水平提供更多的理论依据,提高动物机体健康。Ubiquitination is an important post-translational modification of proteins,which has become an important mechanism for the regulation of signal transduction in different biological processes such as inflammatory signal transduction,and is closely related to inflammatory diseases in animals.Nuclear transcription factor-κB(NF-κB)and NLRP3 inflammasome are two typical driving factors of cytokines,and ubiquitination plays an irreplaceable role in the activation of NF-κB and NLRP3 inflammasome.Therefore,this paper focused on the ubiquitination regulation of NF-κB activated by pathogens,cytokines and free radicals,as well as the ubiquitination regulation of NLRP3 inflammasome activation,in order to provide more theoretical basis for the regulation of the inflammatory level of the body and improve the health of animals.

关 键 词：泛素化 炎症 NF-ΚB NLRP3炎性小体 

分 类 号：S811.3[农业科学—畜牧学]