血清sTREM-1、UCH-L1对重度脑损伤患者预后的评估价值  

Value of Serum sTREM-1 and UCH-L1 in Evaluating the Prognosis of Patients with Severe Brain Injury

作　　者：白高伟 束新辉 刘洎 董文星 段宝民 彭银杰 BAI Gaowei;SHU Xinhui;LIU Ji;DONG Wenxing;DUAN Baomin;PENG Yinjie(Emergency Department,Kaifeng Central Hospital,Kaifeng 475000,China;Department of Cardiothoracic and Gastroenterology,the Second Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]开封市中心医院急诊科,河南开封475000 [2]河南中医药大学第二附属医院心胸胃肠外科,河南郑州450000

出　　处：《河南医学研究》2021年第36期6745-6748,共4页Henan Medical Research

摘　　要：目的探讨血清可溶性髓系细胞触发受体-1(sTREM-1)、泛素羧基末端水解酶-L1(UCH-L1)对重度脑损伤(SBI)患者预后的评估价值。方法选取2018年6月至2020年1月开封市中心医院急诊科收治的170例SBI患者作为研究对象(SBI组),另选取同期门诊体检的80例健康者作为对照组(CON组),根据1 a内SBI患者预后情况将其分为预后良好组(105例)和预后不良组(65例)。检测入组对象血清sTREM-1、UCH-L1的水平,并分析二者对SBI患者预后的评估价值。结果SBI组患者血清sTREM-1、UCH-L1水平高于CON组(P<0.05)。单因素分析显示预后不良组患者血清sTREM-1、UCH-L1、C反应蛋白(CRP)、降钙素原(PCT)水平及年龄、中线移位、Marshall CT分级级别高于预后不良组(P<0.05)。多因素logistic回归分析显示sTREM-1(OR=2.079)、UCH-L1(OR=2.512)、Marshall CT分级(OR=1.737)是SBI患者预后不良的独立危险预测因子(P<0.05)。结论SBI患者血清中sTREM-1、UCH-L1水平升高,且二者是患者预后不良的危险因素,有助于患者预后的早期评估。Objective To investigate the prognostic value of serum soluble triggering receptor-1(sTREM-1)and ubiquitin carboxyl-terminal hydrolase-L1(UCH-L1)in patients with severe brain injury(SBI).Methods A total of 170 patients with SBI admitted to the emergency department of Kaifeng Central Hospital from June 2018 to January 2020 were selected as the research objects(SBI group),and 80 healthy people in the same period of outpatient physical examination were selected as the control group(CON group).According to the prognosis of SBI patients within 1 year,the SBI patients were divided into good prognosis group(105 cases)and poor prognosis group(65 cases).The serum levels of sTREM-1 and UCH-L1 were detected,and their prognostic value was analyzed.Results The serum sTREM-1 and UCH-L1 levels of patients in the SBI group were higher than those in the CON group(P<0.05).Univariate analysis showed that serum sTREM-1,UCH-L1,C-reactive protein(CRP),procalcitonin(PCT)levels,age,midline shift and Marshall CT grade in poor prognosis group were higher than those in poor prognosis group(P<0.05).Multivariate logistic regression analysis showed that sTREM-1(OR=2.079),UCH-L1(OR=2.512)and Marshall CT grade(OR=1.737)were independent predictors of poor prognosis in patients with SBI(P<0.05).Conclusion Serum levels of sTREM-1 and UCH-L1 increase in patients with SBI,and they were risk factors for poor prognosis.The combined detection of sTREM-1 and UCH-L1 is helpful for early evaluation of prognosis.

关 键 词：重度脑损伤 可溶性髓系细胞触发受体-1 泛素羧基末端水解酶-L1 预后 

分 类 号：R651.15[医药卫生—外科学]