晚期结直肠癌化疗患者营养状况与治疗耐受性、疗效及化疗不良反应的关系  

Relationship Between the Nutritional Status and the Treatment Tolerance,Efficacy and Adverse Reactions of Chemotherapy in Patients with Advanced Colorectal Cancer

作　　者：张喜凤[1] 梁宪斌[1] 向梅 张维真[1] ZHANG Xifeng;LIANG Xianbin;XIANG Mei;ZHANG Weizhen(Department of Oncology,Zhengzhou Third People’s Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州市第三人民医院肿瘤内科,河南郑州450000

出　　处：《河南医学研究》2021年第36期6827-6830,共4页Henan Medical Research

摘　　要：目的探究晚期结直肠癌化疗患者营养状况与治疗耐受性、疗效及化疗不良反应的关系。方法回顾性分析郑州市第三人民医院2019年1月至2021年2月收治的66例晚期结直肠癌患者的临床资料,依据患者主观整体评估(PG-SGA)评分将患者分为营养良好组(n=20)、可疑营养不良组(n=22)和中度营养不良组(n=24),比较3组患者营养指标[血清白蛋白(ALB)、血红蛋白(Hb)、淋巴细胞计数]、化疗后耐受性、疗效及化疗不良反应发生状况。结果3组患者ALB、淋巴细胞计数比较,差异有统计学意义(P<0.05);营养良好组患者ALB、淋巴细胞计数水平高于中度营养不良组(P<0.05);可疑营养不良组ALB、淋巴细胞计数水平高于中度营养不良组(P<0.05)。3组间Hb水平比较,差异无统计学意义(P>0.05)。3组患者化疗耐受性比较,差异无统计学意义(P>0.05)。营养良好组患者治疗总有效率(70.00%)高于中度营养不良组(33.33%)(P<0.05);3组患者胃肠道、血液系统、神经系统不良反应发生情况比较,差异无统计学意义(P>0.05);3组患者骨髓抑制比较,差异有统计学意义(P<0.05)。结论晚期结直肠癌不同营养水平的化疗患者治疗耐受性差异不显著,处于中度营养不良患者疗效明显较营养良好患者低,并且营养程度低的患者发生骨髓抑制的可能性越高,提示及时监测患者的营养状态并给予一定的营养支持有利于降低患者不良反应。Objective To explore the relationship between the nutritional status and treatment tolerance,efficacy and adverse reactions of chemotherapy in patients with advanced colorectal cancer.Methods The clinical data of 66 patients with advanced colorectal cancer diagnosed in Zhengzhou Third People’s Hospita from January 2019 to March 2021 were retrospectively analyzed.Based on patient-generated subjective global assessment(PG-SGA),patients were divided into well-nourished group(n=20),suspicious malnutrition group(n=22)and moderate malnourished group(n=24).The nutritional indicators of the three groups of patients[serum albumin(ALB),hemoglobin(Hb)and lymphocyte count],tolerability after chemotherapy,efficacy and the occurrence of adverse chemotherapy reactions were compared.Results There were statistical differences in ALB and lymphocyte counts among three groups(P<0.05).The ALB and lymphocyte count levels of patients in the well-nourished group were higher than those in the moderately malnourished group(P<0.05).The ALB and lymphocyte count levels in the suspicious malnutrition group were higher than those in the moderate malnutrition group(P<0.05).There was no statistical difference in Hb levels among the three groups(P>0.05).There was no statistical difference in chemotherapy tolerance among the three groups(P>0.05).The total effective rate in the well-nourished group(70.00%)was higher than that of the moderately malnourished group(33.33%)(P<0.05).There was no statistical difference in adverse reactions between the gastrointestinal tract,blood system and nervous system of patients in three groups(P>0.05),and There were statistical differences in bone marrow suppression among three groups(P<0.05).Conclusion There is no statistical difference in the treatment tolerance of patients with advanced colorectal cancer with different nutritional levels.The efficacy of patients with moderate malnutrition is lower than that of well-nourished patients,and patients with low nutritional levels are more likely to develop bone marr

关 键 词：晚期结直肠癌 化疗 营养状况 耐受性 不良反应 

分 类 号：R551.2[医药卫生—血液循环系统疾病]