铁催化烯烃硼氢化反应研究型综合实验设计  

Design on research-oriented comprehensive experiment of iron-catalyzed hydroboration of alkenes

作　　者：程秋实 潘鹏聪 商双华 苏伟 CHENG Qiushi;PAN Pengcong;SHANG Shuanghua;SU Wei(College of Science,Hebei University of Science and Technology,Shijiazhuang 050018,China)

机构地区：[1]河北科技大学理学院,河北石家庄050018

出　　处：《实验技术与管理》2021年第11期84-88,共5页Experimental Technology and Management

基　　金：国家自然科学基金项目(21901059);河北省自然科学基金项目(B2018208079,B2018208093);河北科技大学教育教学改革研究项目(2019-YBA13);河北科技大学理工学院大学生创新创业项目(X202013409006)。

摘　　要：该文设计了铁催化烯烃硼氢化反应研究型综合实验。非活化烯烃在氯化亚铁为催化剂、频哪醇联硼酯为硼源、叔丁醇锂为碱的条件下,在甲基叔丁基醚和N-甲基吡咯烷酮为溶剂时能够分别得到反马氏和马氏选择性硼氢化产物。通过条件优化和底物拓展的实验设计,有助于学生掌握惰性气体保护反应的架设流程、薄层色谱分析、柱色谱分离、气相色谱分析及核磁谱图解析等重要实验技能,让学生了解研究有机合成的一般方法,提升学生的实践能力和科研素养。The research-oriented comprehensive experiment based on iron-catalyzed hydroboration of alkenes is designed in this paper. Under the conditions of ferrous chloride as the catalyst, bis(pinacolato)diboron as the boron source and lithium tert-butoxide as the base, the unactivated alkenes can respectively transfer to anti-Markovnikov or Markovnikov hydroboration products with methyl tert-butyl ether and N-methylpyrrolidone as solvent. The experiment contains the condition optimization and substrate expansion,which is beneficial for students to acquire important experimental skills such as the setup process of inert-gas protection reaction, thin layer chromatography,column chromatography, gas chromatography and nuclear magnetic spectrum analysis, so that students can understand the general method of organic synthesis methodology research, which improves their practical ability and scientific research literacy.

关 键 词：硼氢化反应 铁催化 烯烃 研究型综合实验 

分 类 号：O621.3[理学—有机化学]