The hypoxia adaptation of small mammals to plateau and underground burrow conditions  

作　　者：Mengke Li Dan Pan Hong Sun Lei Zhang Han Cheng Tian Shao Zhenlong Wang 

机构地区：[1]School of Life Sciences,Zhengzhou University,Zhengzhou,P.R.China [2]Centre for Nutritional Ecology,Zhengzhou University,Zhengzhou,P.R.China

出　　处：《Animal Models and Experimental Medicine》2021年第4期319-328,共10页动物模型与实验医学（英文）

基　　金：This work was supported by the National Natural Science Foundation of China,Grant No.U2004152.

摘　　要：Oxygen is one of the important substances for the survival of most life systems on the earth,and plateau and underground burrow systems are two typical hypoxic environments.Small mammals living in hypoxic environments have evolved different adaptation strategies,which include increased oxygen delivery,metabolic regulation of physiological responses and other physiological responses that change tissue oxygen utilization.Multiomics predictions have also shown that these animals have evolved different adaptations to extreme environments.In particular,vascular endothelial growth factor(VEGF)and erythropoietin(EPO),which have specific functions in the control of O_(2) delivery,have evolved adaptively in small mammals in hypoxic environments.Naked mole-rats and blind mole-rats are typical hypoxic model animals as they have some resistance to cancer.This review primarily summarizes the main living environment of hypoxia tolerant small mammals,as well as the changes of phenotype,physiochemical characteristics and gene expression mode of their long-term living in hypoxia environment.

关 键 词：hypoxia adaptation multi-omics PLATEAU small mammals underground burrow systems 

分 类 号：R594.3[医药卫生—内科学]