表面活性蛋白A、D在肺纤维化中的作用研究进展  

Research progress on the role of surfactant protein A and D in pulmonary fibrosis

作　　者：苏文瑶 陈铿铿[2] 黄永顺[2] 赵娜[2] SU Wen-yao;CHEN Keng-keng;HUANG Yong-shun;ZHAO Na(School of Public Health,Guangzhou Medical University,Guangzhou,Guangdong 511436,China;不详)

机构地区：[1]广州医科大学公共卫生学院,广东广州511436 [2]广东省职业病防治院广东省职业病防治重点实验室,广东广州510300

出　　处：《中国职业医学》2021年第4期451-456,共6页China Occupational Medicine

基　　金：国家自然科学基金(81903269);广东省自然科学基金(2018A030313569);广东省科技计划项目(2014A020212551);广东省职业病防治重点实验室(2017B030314152)。

摘　　要：肺纤维化是由不同致病因素导致的间质性肺疾病,发病率高,预后差,严重影响患者生活质量;但目前其发病机制尚未完全阐明。表面活性蛋白(SP)-A和SP-D是分布在肺泡气液交界面,由肺泡Ⅱ型上皮细胞和细支气管细胞合成与分泌的脂蛋白复合物。它们是先天免疫系统的重要组成部分,可通过多种调控方式参与宿主防御过程,在调节细胞凋亡、肺部炎症、促进上皮修复过程和维持肺泡结构稳定中起着重要作用。SP-A和SP-D的失调与突变可能是肺纤维化发病的影响因素。血清SP-A、SP-D水平在肺纤维化患者和正常健康人群中存在差异表达,且与肺纤维化病情严重程度相关,被认为是一类灵敏反映肺部上皮细胞损伤的生物标志物,可应用于肺纤维化的诊断、治疗和预后评价。Pulmonary fibrosis is an interstitial lung disease caused by different pathogenic factors. It has the characteristics of high morbidity and poor prognosis, which seriously affects the quality of life of patients. However, its pathogenesis has not yet been fully elucidated. Surfactant protein(SP)-A and SP-D are lipoprotein complexes distributed at the air-liquid interface of alveoli, synthesized and secreted by alveolar type Ⅱ epithelial cells and bronchiolar cells. They are important parts of the innate immune system, which participate in the host defense process through a variety of regulatory methods, and play an important role in regulating cell apoptosis and lung inflammation, promoting the process of epithelial repair and maintaining the stability of alveolar structure. The disorder and mutation of SP-A and SP-D may be the influencing factors of the pathogenesis of pulmonary fibrosis. Serum SP-A and SP-D levels are differentially expressed in patients with pulmonary fibrosis and normal healthy individuals, and are related to the severity of pulmonary fibrosis. They are considered to be a class of biomarkers that sensitively reflect lung epithelial cell damage and can be used in the diagnosis, treatment and prognostic evaluation of pulmonary fibrosis.

关 键 词：表面活性蛋白 肺纤维化 诊断 治疗 预后 研究进展 

分 类 号：R13[医药卫生—劳动卫生]