子痫前期患者血栓弹力图和凝血相关指标变化特点及相关性分析  

Characteristics and correlation analysis of thromboelastogram and coagulation related indexes in patients with preeclampsia

作　　者：高逸之 徐恒仕[2] 陈凤玲[2] 卢佩琪 沈紫丹 GAO Yizhi;XU Hengshi;CHEN Fengling;LU Peiqi;SHEN Zidan(Shanghai MCC Hospital,Shanghai 200941,China;Shanghai Ninth People′s Hospital,Shanghai Jiao Tong University School of Medicine)

机构地区：[1]上海中冶医院,上海200941 [2]上海交通大学医学院附属第九人民医院

出　　处：《中国输血杂志》2021年第11期1207-1209,共3页Chinese Journal of Blood Transfusion

基　　金：国家自然科学基金资助项目(81670735);上海交通大学医学院附属第九人民医院临床研究型MDT项目(201701022);吴阶平医学基金会专项资助项目(320.6750.17259)。

摘　　要：目的研究妊娠晚期子痫前期患者血栓弹力图(TEG)和凝血相关指标变化特点并进行相关性分析。方法选取上海第九人民医院北部院区产科2017年6月到2020年6月间收治的妊娠晚期子痫前期患者88例,作为研究组,同期选取正常产检的妊娠晚期正常孕妇288例,作为对照组。抽取两组研究对象的肘正中静脉血,检测TEG和凝血相关指标,并比较两组研究对象的TEG和凝血相关指标差异,同时分析妊娠晚期子痫前期患者TEG相关指标与凝血相关指标相关性。结果研究组的K值、MA、TT、INR等参数值明显高于对照组(P<0.01),Angle角、PT和APTT等参数均明显低于对照组(P<0.01)。K值和MA值与PT和APTT呈现负相关(P<0.05),与TT、INR及PLT呈现正相关(P<0.05);Angle角与PT和APTT呈现正相关(P<0.05),与TT、INR及PLT呈现负相关(P<0.05)。结论妊娠晚期子痫前期患者常伴有凝血功能障碍,进行TEG检测能有效评估患者凝血状态,有助于指导临床尽早预防、干预,降低患者围产期出血和栓塞性疾病发生风险,值得在临床推广。Objective To observe the characteristics and correlation analysis of thromboelastogram(TEG) and platelet related indexes in patients with preeclampsia in late pregnancy. Methods 88 patients with preeclampsia in late pregnancy treated in the Obstetrics Department of Shanghai Ninth People′s Hospital(Northern Hospital) from June 2017 to June 2020 were selected as observation group, and 288 normal pregnant women in late pregnancy with normal prenatal examination were selected as the control. The median elbow vein blood of the two groups were sampled. The TEG and coagulation related indexes of the two groups were compared, and the relationship between TEG and coagulation related indexes in patients with preeclampsia were analyzed. Results The K, MA, TT, INR and PLT value in the observation group, relative to controls, were significantly higher(P<0.01), but Angle, PT, and APTT value were significantly lower(P<0.01). The variance K and MA were negatively correlated with PT and APTT(P<0.05), but positively correlated with TT, INR and Plt(P<0.05). Angle was positively correlated with PT and APTT(P<0.05), but negatively correlated with TT, INR and Plt(P<0.05). Conclusion Routine TEG detection can effectively evaluate the coagulation state of patients with preeclampsia, who are often accompanied by coagulation dysfunction, help to guide clinical early prevention and intervention, and reduce the risk of perinatal hemorrhage and embolism diseases, which is worthy of popularizing in clinical.

关 键 词：子痫前期患者 血栓弹力图 凝血相关指标 

分 类 号：R446.1[医药卫生—诊断学] R714.245[医药卫生—临床医学]