孕妇补充维生素D对新生儿高胆红素血症的预防作用  

Preventive effect of vitamin D supplementation in pregnant women on neonatal hyperbilirubinemia

作　　者：付林敏 FU Lin-min(Department of Pediatrics,Iron Coal General Hospital of Liaoning Health Industry Group,Tieling 112700,China)

机构地区：[1]辽宁省健康产业集团铁煤总医院儿科,112700

出　　处：《中国实用医药》2021年第34期30-33,共4页China Practical Medicine

摘　　要：目的探究孕妇补充维生素D对新生儿高胆红素血症的预防作用,并就其机制进行分析。方法180例孕早期孕妇,按照随机数字表法分为实验组与对照组,每组90例。实验组孕妇每日补充适量维生素D,对照组孕妇不实施特殊干预。对比两组新生儿高胆红素血症发生情况、总胆红素水平及高胆红素血症新生儿总胆红素达峰时间、黄疸持续时间。结果实验组新生儿高胆红素血症发生率11.11%低于对照组的24.44%,差异具有统计学意义(P<0.05)。实验组新生儿出生后3、5、7 d的总胆红素水平分别为(231.03±12.03)、(265.95±20.15)、(240.13±13.26)μmol/L,均低于对照组的(246.59±26.13)、(298.46±16.53)、(261.30±15.41)μmol/L,差异具有统计学意义(P<0.05)。实验组高胆红素血症新生儿总胆红素达峰时间(3.96±1.01)d、黄疸持续时间(7.56±1.59)d短于对照组的(4.68±0.62)、(8.62±1.03)d,差异有统计学意义(P<0.05)。结论孕妇孕期适量补充维生素D能够显著降低新生儿高胆红素血症发生率,同时还能够加快高胆红素血症患儿病情好转。Objective To analyze the preventive effect of vitamin D supplementation in pregnant women on neonatal hyperbilirubinemia,and explore its mechanism.Methods A total of 180 women in early pregnancy were divided into experimental group and control group according to the random numerical table,with 90 cases in each group.Pregnant women in the experimental group received daily supplementation of vitamin D,and pregnant women in the control group did not implement any special intervention.The occurrence of neonatal hyperbilirubinemia,total bilirubin level,and peak-time of total bilirubin and duration of jaundice in neonates with hyperbilirubinemia were compared between the two groups.Results The incidence of neonatal hyperbilirubinemia 11.11%in the experimental group was lower than 24.44%in the control group,and the difference was statistically significant(P<0.05).The total bilirubin levels of neonates in the experimental group at 3,5,and 7 d after birth were(231.03±12.03),(265.95±20.15),and(240.13±13.26)μmol/L,respectively,which were lower than(246.59±26.13),(298.46±16.53),and(261.30±15.41)μmol/L of the control group,and the differences were statistically significant(P<0.05).The peak-time of total bilirubin and duration of jaundice in neonates with hyperbilirubinemia of the experimental group were(3.96±1.01)and(7.56±1.59)d,which were shorter than(4.68±0.62)and(8.62±1.03)d of the control group,and the difference was statistically significant(P<0.05).Conclusion Appropriate vitamin D supplementation during pregnancy can significantly reduce the incidence of neonatal hyperbilirubinemia,and also accelerate the improvement of neonates with hyperbilirubinemia.

关 键 词：维生素D 高胆红素血症 孕妇 新生儿 预防作用 

分 类 号：R722.1[医药卫生—儿科]